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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

The inventory notes what type of response letter the FDA sent in response to the notice. Notifiers often resubmit notices that FDA previously ceased to evaluate at the notifier’s request, and resubmitted notices commonly receive a letter indicating FDA has no questions, after addressing deficiencies. In the inventory, entries for notices that were later resubmitted link to the newer entry in the final column. Newer entries for notices that were resubmitted include a link to the previous submission below the substance name.

Some GRNs that FDA previously ceased to evaluate at the notifier’s request were later resubmitted as a food additive petition. For each of these cases, the GRN detail page links to the food additive petition.

After issuing a response letter, we may issue a subsequent letter as circumstances warrant. The issue dates of any subsequent letters are listed under the column, "Date of add’l correspondence.”

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


Search and display hints:

  • Select the specific GRN number below to view additional details about any GRAS Notice.
  • To sort by a specific field, click on the column header for that field.
  • To browse the records, use the Show All, First/Previous/Next/Last, and Jump To options at the bottom of the data table.
  • To search for a specific substance/term, enter the term in the Search box and select Show Items to display only those records that contain the selected term. (The search results also includes terms not shown on this page, but included in the full record on the detail page.)
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Records Found: 31 Page 1 of 1
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
  1149
High-selenium Saccharomyces cerevisiae yeast Pending
  1107
Bifidobacterium longum subsp. infantis strain LMG 11588 Pending
  1079
Bifidobacterium longum strain KCTC 12200BP Pending
  1078
Bifidobacterium bifidum strain KCTC 12199BP Pending
  1077
Oat polar lipid extract Pending
  1076
Galacto-oligosaccharides Mar 2, 2023 FDA has no questions (in PDF) (245 kB)
  1075
6'-sialyllactose sodium salt Mar 22, 2023 FDA has no questions (in PDF) (286 kB)
  1074
3'-sialyllactose sodium salt Apr 5, 2023 FDA has no Questions (in PDF) (383 kB)
  1073
Corn bran arabinoxylan Pending
  1072
Lemnaceae fiber Jan 30, 2023 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (229 kB)
  1071
Glucose oxidase enzyme preparation produced by Saccharomyces cerevisiae expressing a gene encoding a glucose oxidase from Aspergillus niger Pending
  1070
Preparations containing six bacteriophages (phage) specific to Salmonella enterica Mar 10, 2023 FDA has no Questions (in PDF) (279 kB)
  758
Lactobacillus helveticus R0052, Bifidobacterium longum subsp. infantis R0033, and Bifidobacterium bifidum R0071 Aug 20, 2018 FDA has no questions (in PDF) (103 kB)
  722
Lactobacillus plantarum Lp-115 Feb 16, 2018 FDA has no questions (in PDF) (67 kB)
  715
Rebaudioside D Oct 24, 2017 FDA has no questions (in PDF) (69 kB)
  714
Subtilisin from Bacillus amyloliquefaciens produced in Bacillus subtilis Feb 6, 2018 FDA has no questions (in PDF) (53 kB)
  712
Calcium acetate Feb 5, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (44 kB)
  711
Glucan Dec 26, 2017 FDA has no questions (in PDF) (49 kB)
  710
Basic methacrylate copolymer Dec 8, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (50 kB)
  708
Triacylglycerol lipase from Rhizopus oryzae produced in Aspergillus niger Oct 10, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (52 kB)
  706
Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Aug 17, 2017 FDA has no questions (in PDF) (93 kB)
  704
Corn oil (by-product of ethanol production) Oct 10, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (67 kB)
  703
Alpha-glucosidase from Aspergillus niger produced by Trichoderma reesi Nov 9, 2017 FDA has no questions (in PDF) (128 kB)
  695
Dimethyl ether Aug 29, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (46 kB)
  693
D-psicose Aug 28, 2017 FDA has no questions (in PDF) (97 kB)
  684
Mung bean protein isolate Aug 4, 2017 FDA has no questions (in PDF) (119 kB)
  439
Iron complex of tartaric acid Nov 9, 2012 At the notifier's request, FDA ceased to evaluate this notice
  216
Lipase enzyme preparation from Rhizopus oryzae May 18, 2007 FDA has no questions
  196
Bovine milk basic protein fraction Sep 1, 2006 FDA has no questions
  186
Soy lecithin enzymatically modified to have increased phosphatidylserine Jul 20, 2006 FDA has no questions
  107
Polydextrose Oct 17, 2002 At the notifier's request, FDA ceased to evaluate this notice

GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
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