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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 19 Page 1 of 1
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
758 Lactobacillus helveticus R0052, Bifidobacterium longum subsp. infantis R0033, and Bifidobacterium bifidum R0071 Aug 20, 2018 FDA has no questions (in PDF) (103 kB)
722 Lactobacillus plantarum Lp-115 Feb 16, 2018 FDA has no questions (in PDF) (67 kB)
715 Rebaudioside D Oct 24, 2017 FDA has no questions (in PDF) (69 kB)
714 Subtilisin from Bacillus amyloliquefaciens produced in Bacillus subtilis Feb 6, 2018 FDA has no questions (in PDF) (53 kB)
712 Calcium acetate Feb 5, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (44 kB)
711 Glucan Dec 26, 2017 FDA has no questions (in PDF) (49 kB)
710 Basic methacrylate copolymer Dec 8, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (50 kB)
708 Triacylglycerol lipase from Rhizopus oryzae produced in Aspergillus niger Oct 10, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (52 kB)
706 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Aug 17, 2017 FDA has no questions (in PDF) (93 kB)
704 Corn oil (by-product of ethanol production) Oct 10, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (67 kB)
703 Alpha-glucosidase from Aspergillus niger produced by Trichoderma reesi Nov 9, 2017 FDA has no questions (in PDF) (128 kB)
695 Dimethyl ether Aug 29, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (46 kB)
693 D-psicose Aug 28, 2017 FDA has no questions (in PDF) (97 kB)
684 Mung bean protein isolate Aug 4, 2017 FDA has no questions (in PDF) (119 kB)
439 Iron complex of tartaric acid Nov 9, 2012 At notifier's request, FDA ceased to evaluate the notice
216 Lipase enzyme preparation from Rhizopus oryzae May 18, 2007 FDA has no questions
196 Bovine milk basic protein fraction Sep 1, 2006 FDA has no questions
186 Soy lecithin enzymatically modified to have increased phosphatidylserine Jul 20, 2006 FDA has no questions
107 Polydextrose Oct 17, 2002 At notifier's request, FDA ceased to evaluate the notice

GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

2362  

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