• Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

GRAS Notices

  • Print
  • Share
  • E-mail
-

The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

The inventory notes what type of response letter the FDA sent in response to the notice. Notifiers often resubmit notices that FDA previously ceased to evaluate at the notifier’s request, and resubmitted notices commonly receive a letter indicating FDA has no questions, after addressing deficiencies. In the inventory, entries for notices that were later resubmitted link to the newer entry in the final column. Newer entries for notices that were resubmitted include a link to the previous submission below the substance name.

Some GRNs that FDA previously ceased to evaluate at the notifier’s request were later resubmitted as a food additive petition. For each of these cases, the GRN detail page links to the food additive petition.

After issuing a response letter, we may issue a subsequent letter as circumstances warrant. The issue dates of any subsequent letters are listed under the column, "Date of add’l correspondence.”

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


Search and display hints:

  • Select the specific GRN number below to view additional details about any GRAS Notice.
  • To sort by a specific field, click on the column header for that field.
  • To browse the records, use the Show All, First/Previous/Next/Last, and Jump To options at the bottom of the data table.
  • To search for a specific substance/term, enter the term in the Search box and select Show Items to display only those records that contain the selected term. (The search results also includes terms not shown on this page, but included in the full record on the detail page.)
  • The search results will return hits of records containing words that include the search term. For example, a search for the color red will return results that include terms such as reduce, ingredient, and cultured. To limit results to only the searched term, place a space before and after the word in the basic search or in the advanced search “this exact phrase” field.
Download GRAS Notices data in Microsoft Excel web format Download data from this searchable database in Excel format. If you need help accessing information in different file formats, see Instructions for Downloading Viewers and Players.

Fill in one or more of the criteria to search for. Separate multiple word (or character string) entries with spaces.
(Character strings may be whole or partial words or numbers, and may include common punctuation as is found in chemical names.)




Search within these results
Records Found: 192 Show All Page 1 of 4
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
  1162
Fungal oil (≥38% arachidonic acid (ARA)) from Mortierella alpina FJRK-MA01 Feb 8, 2024 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (236 kB)
  1156
Algal oil (≥35% docosahexaenoic acid) from Schizochytrium sp. FJRK-SCH3 Feb 8, 2024 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (204 kB)
  1135
Galacto-oligosaccharides Nov 3, 2023 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (133 kB)
  1124
β-glucans from Hericium erinaceus strain BCRC 35669 Sep 28, 2023 At the notifier's request, FDA Ceased to evaluate this notice (in PDF) (209 kB)
  1101
Dried biomass of Chlamydomonas reinhardtii strain TAI114 Sep 1, 2023 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (161 kB)
  1072
Lemnaceae fiber Jan 30, 2023 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (229 kB)
  1050
High 2-palmitic acid vegetable oil Jul 18, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (175 kB)
  1044
Calcium disodium ethylenediaminetetraacetic acid May 25, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (118 kB)
  1042
Menaquinone-7 derived from a specific strain of Bacillus subtilis natto Apr 3, 2023 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (188 kB)
  1040
2'-fucosyllactose Sep 22, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (116 kB)
  1027
Miracle fruit (Synsepalum dulcificum) powder Dec 22, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (137 kB)
  1023
Monosodium L-5-methyltetrahydrofolate Jan 25, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (85 kB)
  1020
Protein from Helianthus annuus (sunflower protein) Jun 14, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (101 kB)
  1012
Powdered sap from Angelica keiskei (ashitaba) containing 8% chalcones (ashitaba sap) Apr 7, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (108 kB)
  1009
Water-soluble palm fruit extract Jun 24, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (129 kB)
  1007
Bacillus subtilis strain R0179 Dec 16, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (184 kB)
  1005
β-Lactoglobulin from cow milk Mar 3, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF)
  1004
Maltosyltrehalose syrup Jan 20, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (84 kB)
  1000
Phycocyanin-rich extract of Galdieria sulphuraria (G. sulphuraria strain FCC3424) Mar 8, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (160 kB)
  998
Corn bran arabinoxylan Oct 25, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (101 kB)
  994
Miracle fruit (Synsepalum dulcificum), in pulp, powder, or protein forms Oct 26, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (140 kB)
  992
White mulberry (Morus alba Linn) leaf extract May 6, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (97 kB)
  987
2'-fucosyllactose Feb 2, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (236 kB)
  984
Wolffia globosa Oct 8, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (429 kB)
  976
Sodium hyaluronate May 24, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (185 kB)
  973
Maple wood fiber May 13, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (169 kB)
  962
Rice bran wax Mar 17, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (138 kB)
  961
β-glucan derived from Agrobacterium sp. CCTCC No. M2010020 May 19, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (229 kB)
  958
Fungal oil (≥40% arachidonic acid) from Mortierella alpina strain AF Mar 26, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (94 kB)
  954
Fibrillated cellulose Jun 10, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (111 kB)
  942
Whey permeate Dec 21, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (189 kB)
  941
Oat polar lipid extract Jun 11, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (124 kB)
  935
L-carnitine-L-tartrate Nov 30, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (242 kB)
  930
Silk fibroin derived from Bombyx mori cocoons May 25, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (128 kB)
  924
2'-fucosyllactose Nov 23, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF)
  912
Trehalose Oct 1, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (141 kB)
  909
Whey protein containing 41% alpha-lactalbumin Sep 8, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (127 kB)
  894
White mulberry leaf extract Nov 19, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (201 kB)
  893
D-psicose Jun 5, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (58 kB)
  892
Refined shea butter Jul 7, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (162 kB)
  890
Corn oil derived from distillers grains Dec 23, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (189 kB)
  889
Spermidine rich wheat germ extract Mar 20, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (236 kB)
  888
Preparation containing three bacterial phages specific to Salmonella Feb 28, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (36 kB)
  875
Bifidobacterium animalis subsp. lactis AD011 Oct 30, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (258 kB)
  952
  874
Corn protein Apr 29, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (44 kB)
  867
Rebaudioside M Sep 3, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (36 kB)
  866
Lipase from Penicillium camemberti Feb 5, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (257 kB)
  860
Algal oil (36% docosahexaenoic acid) from Schizochytrium sp. strain DHF Sep 3, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (59 kB)
  859
2'-fucosyllactose Sep 6, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (106 kB)
  845
Lactobacillus rhamnosus LGG Oct 30, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (121 kB)

Show All 

jump to page of 4 


GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
-
-