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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 25 Page 1 of 1
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
964 Lysophospholipase enzyme preparation from Aspergillus niger produced by Trichoderma reesei Pending
891 Cellulase produced by Trichoderma reesei Pending
863 β-lactoglobulin produced by Trichoderma reesei Mar 25, 2020 FDA has no questions (in PDF) (637 KB)
853 Lysozyme produced by Trichoderma reesei May 27, 2020 FDA has no questions (in PDF) (552 kB)
817 Serine endopeptidase from Malbranchea cinnamomea produced in Trichoderma reesei Aug 26, 2019 FDA has no questions (in PDF) (68 KB)
808 Lipase from Aspergillus tubingensis produced in Trichoderma reesei May 28, 2019 FDA has no questions (in PDF) (79 kB)
756 Endo-1,4-beta-glucanase from Trichoderma reesei Sep 12, 2018 FDA has no questions (in PDF) (93 KB)
727 Trehalase from Trichoderma reesei produced in Trichoderma reesei Mar 5, 2018 FDA has no questions (in PDF) (61 kB)
707 Glucose oxidase from Penicillium produced in Trichoderma reesei Nov 24, 2017 FDA has no questions (in PDF) (51 kB)
680 Alpha-L-arabinofuranosidase from Talaromyces pinophilus produced by Trichoderma reesei May 24, 2017 FDA has no questions (in PDF) (101 kB)
675 Xylanase enzyme preparation produced by Trichoderma reesei carrying a xylanase gene from Talaromyces leycettanus Apr 6, 2017 FDA has no questions (in PDF) (76 kB)
653 Lysophospholipase from Aspergillus nishimurae expressed in Trichoderma reesei. Oct 13, 2016 FDA has no questions
631 Triacylglycerol lipase from Fusarium oxysporum produced in Trichoderma reesei Jul 18, 2016 FDA has no questions
628 endo-1,4-beta-xylanase from Trichoderma reesei Sep 14, 2016 FDA has no questions
567 Xylanase from Trichoderma reesei May 8, 2015 FDA has no questions
566 Mannanase from Trichoderma reesei May 21, 2015 FDA has no questions
558 Pectin esterase from Aspergillus tubingensis expressed in Trichoderma reesei Jul 23, 2015 FDA has no questions
557 Polygalacturonase from Aspergillus tubingensis expressed in Trichoderma reesei Jul 23, 2015 FDA has no questions
524 Phospholipase A2 enzyme preparation from Trichoderma reesei carrying a phospholipase A2 gene from Aspergillus nishimurae Nov 10, 2014 FDA has no questions
490 Phospholipase A2 enzyme preparation from Trichoderma reesei Mar 5, 2014 At the notifier's request, FDA ceased to evaluate this notice.
372 Glucoamylase enzyme preparation from Trichoderma reesei expressing the glucoamylase gene from T. reesei (glucoamylase enzyme preparation) Jul 25, 2011 FDA has no questions
333 Acid fungal protease enzyme preparation from Trichoderma reesei expressing the gene encoding acid fungal protease from T. reesei Sep 24, 2010 FDA has no questions
315 Transglucosidase enzyme preparation from Trichoderma reesei expressing the gene encoding transglucosidase from Aspergillus niger May 4, 2010 FDA has no questions
230 Chymosin enzyme preparation from Trichoderma reesei expressing the bovine prochymosin B gene Feb 19, 2008 FDA has no questions
32 Pectin lyase derived from Trichoderma reesei carrying a gene encoding pectin lyase from Aspergillus niger Apr 20, 2000 FDA has no questions

GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

2362  

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