• Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

GRAS Notices

  • Print
  • Share
  • E-mail
-

The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

The inventory notes what type of response letter the FDA sent in response to the notice. Notifiers often resubmit notices that FDA previously ceased to evaluate at the notifier’s request, and resubmitted notices commonly receive a letter indicating FDA has no questions, after addressing deficiencies. In the inventory, entries for notices that were later resubmitted link to the newer entry in the final column. Newer entries for notices that were resubmitted include a link to the previous submission below the substance name.

Some GRNs that FDA previously ceased to evaluate at the notifier’s request were later resubmitted as a food additive petition. For each of these cases, the GRN detail page links to the food additive petition.

After issuing a response letter, we may issue a subsequent letter as circumstances warrant. The issue dates of any subsequent letters are listed under the column, "Date of add’l correspondence.”

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


Search and display hints:

  • Select the specific GRN number below to view additional details about any GRAS Notice.
  • To sort by a specific field, click on the column header for that field.
  • To browse the records, use the Show All, First/Previous/Next/Last, and Jump To options at the bottom of the data table.
  • To search for a specific substance/term, enter the term in the Search box and select Show Items to display only those records that contain the selected term. (The search results also includes terms not shown on this page, but included in the full record on the detail page.)
  • The search results will return hits of records containing words that include the search term. For example, a search for the color red will return results that include terms such as reduce, ingredient, and cultured. To limit results to only the searched term, place a space before and after the word in the basic search or in the advanced search “this exact phrase” field.
Download GRAS Notices data in Microsoft Excel web format Download data from this searchable database in Excel format. If you need help accessing information in different file formats, see Instructions for Downloading Viewers and Players.
Search within these results
Records Found: 32 Page 1 of 1
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
  1150
Triacylglycerol lipase enzyme preparation produced by Trichoderma reesei expressing a gene for triacylglycerol lipase from Thermomyces lanuginosis Pending
  1121
Fructanase enzyme preparation produced by Trichoderma reesei expressing the gene encoding fructanase from Lactobacillus sp. Pending
  1110
Polygalacturonase enzyme preparation produced by Trichoderma reesei expressing a gene encoding a polygalacturonase from Aspergillus kawachii Pending
  1102
Invertase enzyme preparation produced by Trichoderma reesei expressing a gene for invertase from Aspergillus niger Pending
  1048
Aminopeptidase enzyme preparation produced by Trichoderma reesei expressing a gene encoding an aminopeptidase from Aspergillus clavatus Pending
  1030
Cellulase enzyme preparation produced by Aspergillus niger genetically engineered to express a cellulase gene from Trichoderma reesei Feb 15, 2023 FDA has no questions (in PDF) (286 kB)
  981
Sterol esterase enzyme preparation produced by Trichoderma reesei expressing a gene encoding sterol esterase from Melanocarpus albomyces May 10, 2022 FDA has no questions (in PDF) (255 kB)
  964
Lysophospholipase enzyme preparation from Aspergillus niger produced by Trichoderma reesei Sep 9, 2021 FDA has no questions (in PDF) (158 kB)
  891
Cellulase produced by Trichoderma reesei Oct 20, 2020 FDA has no questions (in PDF)
  863
β-lactoglobulin produced by Trichoderma reesei Mar 25, 2020 FDA has no questions (in PDF) (637 kB)
  853
Lysozyme produced by Trichoderma reesei May 27, 2020 FDA has no questions (in PDF) (552 kB)
  817
Serine endopeptidase from Malbranchea cinnamomea produced in Trichoderma reesei Aug 26, 2019 FDA has no questions (in PDF) (68 kB)
  808
Lipase from Aspergillus tubingensis produced in Trichoderma reesei May 28, 2019 FDA has no questions (in PDF) (79 kB)
  756
Endo-1,4-beta-glucanase from Trichoderma reesei Sep 12, 2018 FDA has no questions (in PDF) (93 kB)
  727
Trehalase from Trichoderma reesei produced in Trichoderma reesei Mar 5, 2018 FDA has no questions (in PDF) (61 kB)
  707
Glucose oxidase from Penicillium produced in Trichoderma reesei Nov 24, 2017 FDA has no questions (in PDF) (51 kB)
  680
Alpha-L-arabinofuranosidase from Talaromyces pinophilus produced by Trichoderma reesei May 24, 2017 FDA has no questions (in PDF) (101 kB)
  675
Xylanase enzyme preparation produced by Trichoderma reesei carrying a xylanase gene from Talaromyces leycettanus Apr 6, 2017 FDA has no questions (in PDF) (76 kB)
  653
Lysophospholipase from Aspergillus nishimurae expressed in Trichoderma reesei. Oct 13, 2016 FDA has no questions
  631
Triacylglycerol lipase from Fusarium oxysporum produced in Trichoderma reesei Jul 18, 2016 FDA has no questions
  628
endo-1,4-beta-xylanase from Trichoderma reesei Sep 14, 2016 FDA has no questions
  567
Xylanase from Trichoderma reesei May 8, 2015 FDA has no questions
  566
Mannanase from Trichoderma reesei May 21, 2015 FDA has no questions
  558
Pectin esterase from Aspergillus tubingensis expressed in Trichoderma reesei Jul 23, 2015 FDA has no questions
  557
Polygalacturonase from Aspergillus tubingensis expressed in Trichoderma reesei Jul 23, 2015 FDA has no questions
  524
Phospholipase A2 enzyme preparation from Trichoderma reesei carrying a phospholipase A2 gene from Aspergillus nishimurae Nov 10, 2014 FDA has no questions
  490
Phospholipase A2 enzyme preparation from Trichoderma reesei Mar 5, 2014 At the notifier's request, FDA ceased to evaluate this notice
  372
Glucoamylase enzyme preparation from Trichoderma reesei expressing the glucoamylase gene from T. reesei (glucoamylase enzyme preparation) Jul 25, 2011 FDA has no questions
  333
Acid fungal protease enzyme preparation from Trichoderma reesei expressing the gene encoding acid fungal protease from T. reesei Sep 24, 2010 FDA has no questions
  315
Transglucosidase enzyme preparation from Trichoderma reesei expressing the gene encoding transglucosidase from Aspergillus niger May 4, 2010 FDA has no questions
  230
Chymosin enzyme preparation from Trichoderma reesei expressing the bovine prochymosin B gene Feb 19, 2008 FDA has no questions
  32
Pectin lyase derived from Trichoderma reesei carrying a gene encoding pectin lyase from Aspergillus niger Apr 20, 2000 FDA has no questions

GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
-
-