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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

The inventory notes what type of response letter the FDA sent in response to the notice. Notifiers often resubmit notices that FDA previously ceased to evaluate at the notifier’s request, and resubmitted notices commonly receive a letter indicating FDA has no questions, after addressing deficiencies. In the inventory, entries for notices that were later resubmitted link to the newer entry in the final column. Newer entries for notices that were resubmitted include a link to the previous submission below the substance name.

Some GRNs that FDA previously ceased to evaluate at the notifier’s request were later resubmitted as a food additive petition. For each of these cases, the GRN detail page links to the food additive petition.

After issuing a response letter, we may issue a subsequent letter as circumstances warrant. The issue dates of any subsequent letters are listed under the column, "Date of add’l correspondence.”

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


Search and display hints:

  • Select the specific GRN number below to view additional details about any GRAS Notice.
  • To sort by a specific field, click on the column header for that field.
  • To browse the records, use the Show All, First/Previous/Next/Last, and Jump To options at the bottom of the data table.
  • To search for a specific substance/term, enter the term in the Search box and select Show Items to display only those records that contain the selected term. (The search results also includes terms not shown on this page, but included in the full record on the detail page.)
  • The search results will return hits of records containing words that include the search term. For example, a search for the color red will return results that include terms such as reduce, ingredient, and cultured. To limit results to only the searched term, place a space before and after the word in the basic search or in the advanced search “this exact phrase” field.
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Records Found: 20 Page 1 of 1
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
  1062
Saccharomyces cerevisiae strain OYR-185 Apr 5, 2023 FDA has no questions (in PDF) (214 kB)
  905
Bacillus subtilis SG188 Jun 8, 2020 FDA has no questions (in PDF) (659 kB)
  903
Quillaia extract type 2 Apr 21, 2021 FDA has no questions (in PDF) (195 kB)
  855
Bifidobacterium animalis subsp. lactis strain R0421 Feb 5, 2020 FDA has no questions (in PDF) (634 kB)
  477
Long-chain inulin Mar 4, 2014 FDA has no questions
  394
Dried biomass of Arthrospira platensis, also known as Spirulina platensis (Spirulina) Jun 4, 2012 FDA has no questions; some uses may require a color additive listing Dec 27, 2012
  248
Sucrose fatty acid esters (i.e., sucrose monoesters of lauric acid, palmitic acid, and stearic acid) manufactured by reaction of sucrose with vinyl esters of lauric, palmitic, and stearic acids Oct 24, 2008 FDA has no questions
  159
Carnobacterium maltaromaticum strain CB1 May 27, 2005 FDA has no questions
  132
Lactase enzyme preparation from Aspergillus niger Dec 12, 2003 FDA has no questions
  131
High 2-palmitic vegetable oil Dec 4, 2003 FDA has no questions May 7, 2004
  130
Bovine milk-derived lactoferrin Aug 21, 2003 FDA has no questions May 27, 2004
  129
Sucrose fatty acid esters Nov 7, 2003 FDA has no questions
  128
Skim milk or dextrose cultured with Propionibacterium freudenreichii subsp. shermanii Nov 26, 2003 FDA has no questions
  127
Spirulina, the dried biomass of Arthrospira platensis
   (Resubmission of GRN 101)
Oct 6, 2003 FDA has no questions; some uses may require a color additive listing
  126
alpha-Amylase enzyme preparation from Pseudomonas fluorescens Biovar I expressing a gene encoding a hybrid alpha-amylase derived from three microorganisms within the order Thermococcales Sep 26, 2003 FDA has no questions
  125
Grape seed extract and grape pomace extract
   (Resubmission of GRN 93)
Aug 18, 2003 FDA has no questions; some uses may require a color additive listing
  124
Grape seed extract Aug 1, 2003 FDA has no questions
  71
White mineral oil, USP (viscosity ISO 100 )
   (Resubmission of GRN 40)
Apr 20, 2001 FDA has no questions
  40
Mineral oil Dec 11, 2000 Notice does not provide a basis for a GRAS determination
  71
  35
Hempseed oil Aug 24, 2000 Notice does not provide a basis for a GRAS determination

GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
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