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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

The inventory notes what type of response letter the FDA sent in response to the notice. Notifiers often resubmit notices that FDA previously ceased to evaluate at the notifier’s request, and resubmitted notices commonly receive a letter indicating FDA has no questions, after addressing deficiencies. In the inventory, entries for notices that were later resubmitted link to the newer entry in the final column. Newer entries for notices that were resubmitted include a link to the previous submission below the substance name.

Some GRNs that FDA previously ceased to evaluate at the notifier’s request were later resubmitted as a food additive petition. For each of these cases, the GRN detail page links to the food additive petition.

After issuing a response letter, we may issue a subsequent letter as circumstances warrant. The issue dates of any subsequent letters are listed under the column, "Date of add’l correspondence.”

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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Search within these results
Records Found: 192 Show 50 records at a time
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
  1162
Fungal oil (≥38% arachidonic acid (ARA)) from Mortierella alpina FJRK-MA01 Feb 8, 2024 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (236 kB)
  1156
Algal oil (≥35% docosahexaenoic acid) from Schizochytrium sp. FJRK-SCH3 Feb 8, 2024 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (204 kB)
  1135
Galacto-oligosaccharides Nov 3, 2023 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (133 kB)
  1124
β-glucans from Hericium erinaceus strain BCRC 35669 Sep 28, 2023 At the notifier's request, FDA Ceased to evaluate this notice (in PDF) (209 kB)
  1101
Dried biomass of Chlamydomonas reinhardtii strain TAI114 Sep 1, 2023 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (161 kB)
  1072
Lemnaceae fiber Jan 30, 2023 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (229 kB)
  1050
High 2-palmitic acid vegetable oil Jul 18, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (175 kB)
  1044
Calcium disodium ethylenediaminetetraacetic acid May 25, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (118 kB)
  1042
Menaquinone-7 derived from a specific strain of Bacillus subtilis natto Apr 3, 2023 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (188 kB)
  1040
2'-fucosyllactose Sep 22, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (116 kB)
  1027
Miracle fruit (Synsepalum dulcificum) powder Dec 22, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (137 kB)
  1023
Monosodium L-5-methyltetrahydrofolate Jan 25, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (85 kB)
  1020
Protein from Helianthus annuus (sunflower protein) Jun 14, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (101 kB)
  1012
Powdered sap from Angelica keiskei (ashitaba) containing 8% chalcones (ashitaba sap) Apr 7, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (108 kB)
  1009
Water-soluble palm fruit extract Jun 24, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (129 kB)
  1007
Bacillus subtilis strain R0179 Dec 16, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (184 kB)
  1005
β-Lactoglobulin from cow milk Mar 3, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF)
  1004
Maltosyltrehalose syrup Jan 20, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (84 kB)
  1000
Phycocyanin-rich extract of Galdieria sulphuraria (G. sulphuraria strain FCC3424) Mar 8, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (160 kB)
  998
Corn bran arabinoxylan Oct 25, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (101 kB)
  994
Miracle fruit (Synsepalum dulcificum), in pulp, powder, or protein forms Oct 26, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (140 kB)
  992
White mulberry (Morus alba Linn) leaf extract May 6, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (97 kB)
  987
2'-fucosyllactose Feb 2, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (236 kB)
  984
Wolffia globosa Oct 8, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (429 kB)
  976
Sodium hyaluronate May 24, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (185 kB)
  973
Maple wood fiber May 13, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (169 kB)
  962
Rice bran wax Mar 17, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (138 kB)
  961
β-glucan derived from Agrobacterium sp. CCTCC No. M2010020 May 19, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (229 kB)
  958
Fungal oil (≥40% arachidonic acid) from Mortierella alpina strain AF Mar 26, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (94 kB)
  954
Fibrillated cellulose Jun 10, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (111 kB)
  942
Whey permeate Dec 21, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (189 kB)
  941
Oat polar lipid extract Jun 11, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (124 kB)
  935
L-carnitine-L-tartrate Nov 30, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (242 kB)
  930
Silk fibroin derived from Bombyx mori cocoons May 25, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (128 kB)
  924
2'-fucosyllactose Nov 23, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF)
  912
Trehalose Oct 1, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (141 kB)
  909
Whey protein containing 41% alpha-lactalbumin Sep 8, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (127 kB)
  894
White mulberry leaf extract Nov 19, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (201 kB)
  893
D-psicose Jun 5, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (58 kB)
  892
Refined shea butter Jul 7, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (162 kB)
  890
Corn oil derived from distillers grains Dec 23, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (189 kB)
  889
Spermidine rich wheat germ extract Mar 20, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (236 kB)
  888
Preparation containing three bacterial phages specific to Salmonella Feb 28, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (36 kB)
  875
Bifidobacterium animalis subsp. lactis AD011 Oct 30, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (258 kB)
  952
  874
Corn protein Apr 29, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (44 kB)
  867
Rebaudioside M Sep 3, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (36 kB)
  866
Lipase from Penicillium camemberti Feb 5, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (257 kB)
  860
Algal oil (36% docosahexaenoic acid) from Schizochytrium sp. strain DHF Sep 3, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (59 kB)
  859
2'-fucosyllactose Sep 6, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (106 kB)
  845
Lactobacillus rhamnosus LGG Oct 30, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (121 kB)
  837
Hydroxytyrosol Jun 5, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (54 kB)
  835
Ilex guayusa leaf extract May 22, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (35 kB)
  830
Chicory flour May 22, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (54 kB)
  826
Dihydroquercetin Sep 25, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (35 kB)
  820
Lactobacillus fermentum CECT5716 Apr 3, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (35 kB)
  794
Shiitake, pea, and rice protein fermented with Lentinula edodes Nov 9, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (53 kB)
  782
L-arabinose Aug 29, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (47 kB)
  762
Carnobacterium divergens M35 preparation Aug 14, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (31 kB)
  755
D-psicose May 10, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (56 kB)
  748
Tomato powder Apr 19, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (44 kB)
  723
Benzalkonium chloride Dec 18, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (41 kB)
  718
Calcium acid pyrophosphate Oct 17, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (32 kB)
  716
Bovine milk osteopontin Feb 1, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (32 kB)
  712
Calcium acetate Feb 5, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (44 kB)
  710
Basic methacrylate copolymer Dec 8, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (50 kB)
  708
Triacylglycerol lipase from Rhizopus oryzae produced in Aspergillus niger Oct 10, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (52 kB)
  704
Corn oil (by-product of ethanol production) Oct 10, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (67 kB)
  698
Paramylon isolate from Euglena gracilis Jul 19, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (105 kB)
  697
Dried biomass of Euglena gracilis Jul 19, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (105 kB)
  696
Dolomite Oct 3, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (53 kB)
  695
Dimethyl ether Aug 29, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (46 kB)
  692
Quinoa sprout extract Nov 3, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (33 kB)
  690
Fruit and vegetable vitamin extract Aug 1, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (117 kB)
  688
Sodium thiocyanate Aug 25, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (47 kB)
  687
Inulin from Agave tequilana May 8, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (54 kB)
  678
Alpha-cyclodextrin Apr 14, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (49 kB)
  671
Galacto-oligosaccharides (GOS) Apr 11, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (62 kB)
  665
Lactoperoxidase system Dec 14, 2016 At the notifier's request, FDA ceased to evaluate this notice
  663
Distarch phosphate Sep 30, 2016 At the notifier's request, FDA ceased to evaluate this notice
  658
Grapefruit extract Sep 28, 2016 At the notifier's request, FDA ceased to evaluate this notice
  655
Rice bran wax Sep 20, 2016 At the notifier's request, FDA ceased to evaluate this notice
  647
D-psicose Oct 11, 2016 At the notifier's request, FDA ceased to evaluate this notice
  643
Phosphatidylserine derived from fish Jul 1, 2016 At the notifier's request, FDA ceased to evaluate this notice
  637
Phosphatidylserine derived from soy lecithin Aug 4, 2016 At the notifier's request, FDA ceased to evaluate this notice
  636
Phosphatidylserine derived from sunflower lecithin Jul 1, 2016 At the notifier's request, FDA ceased to evaluate this notice
  630
Preparation containing the bacterial monophages, Fo1a and S16, specific to Salmonella May 17, 2016 At the notifier's request, FDA ceased to evaluate this notice
  629
Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Jul 15, 2016 At the notifier's request, FDA ceased to evaluate this notice
  622
Emulsified fish oil May 13, 2016 At the notifier's request, FDA ceased to evaluate this notice
  621
Emulsified algal oil May 13, 2016 At the notifier's request, FDA ceased to evaluate this notice
  617
α-amylase from Cytophaga sp. produced in Bacillus licheniformis Apr 8, 2016 At the notifier's request, FDA ceased to evaluate this notice
  613
Apple peel powder Mar 8, 2016 At the notifier's request, FDA ceased to evaluate this notice
  612
Fractionated whey protein isolate containing cows milk derived lactoferrin, lactoperoxidase, and transforming growth factor β2 May 19, 2016 At the notifier's request, FDA ceased to evaluate this notice
  611
Fractionated whey protein isolate containing cows milk derived lactoferrin, lactoperoxidase, and transforming growth factor β2 Apr 15, 2016 At the notifier's request, FDA ceased to evaluate this notice
  595
gamma-aminobutyric acid Nov 10, 2015 At the notifier's request, FDA ceased to evaluate this notice
  590
Pyrroloquinoline quinone Jan 18, 2016 At the notifier's request, FDA ceased to evaluate this notice
  625
  582
Inulin from Agave tequilana Nov 25, 2015 At the notifier's request, FDA ceased to evaluate this notice
  570
Magnesium lactate Jan 26, 2016 At the notifier's request, FDA ceased to evaluate this notice
  568
Apoaequorin Oct 21, 2015 At the notifier's request, FDA ceased to evaluate this notice
  562
Bacillus subtilis Apr 2, 2015 At the notifier's request, FDA ceased to evaluate this notice
  561
Bacillus pumilus Apr 2, 2015 At the notifier's request, FDA ceased to evaluate this notice
  560
Bacillus licheniformis Apr 2, 2015 At the notifier's request, FDA ceased to evaluate this notice
  559
Bacillus coagulans Apr 2, 2015 At the notifier's request, FDA ceased to evaluate this notice
  549
Sodium salts of fatty acids from Mortierella alpina oil Jun 5, 2015 At the notifier's request, FDA ceased to evaluate this notice
  540
Soybean leghemoglobin from Pichia pastoris Nov 10, 2015 At the notifier's request, FDA ceased to evaluate this notice
  737
  539
Fish meal-based lipid extract Jun 15, 2015 At the notifier's request, FDA ceased to evaluate this notice
  530
Extract of Apocynum venetum leaves Nov 5, 2014 At the notifier's request, FDA ceased to evaluate this notice
  513
Dried biomass of Euglena gracilis containing beta-1,3-glucan from Euglena gracilis Jul 9, 2014 At the notifier's request, FDA ceased to evaluate this notice
  508
Salts from dried mineral water (65% NaCl) Sep 24, 2014 At the notifier's request, FDA ceased to evaluate this notice
  490
Phospholipase A2 enzyme preparation from Trichoderma reesei Mar 5, 2014 At the notifier's request, FDA ceased to evaluate this notice
  488
Benzalkonium chloride May 15, 2014 At the notifier's request, FDA ceased to evaluate this notice
  474
Piperine derived from the fruits of Piper nigrum L (black pepper) or P. longum (long pepper) Sep 19, 2013 At the notifier's request, FDA ceased to evaluate this notice
  463
Lactobacillus acidophilus strain NP 28, Lactobacillus acidophilus strain NP51, Lactobacillus subsp. lactis strain NP7, and Pediococcus acidilactici strain NP3 Jan 16, 2014 At the notifier's request, FDA ceased to evaluate this notice
  459
Olive pulp extract Mar 25, 2013 At the notifier's request, FDA ceased to evaluate this notice
  450
Chlorella protothecoides S106 flour with 40-70% lipid Apr 19, 2013 At the notifier's request, FDA ceased to evaluate this notice
  469
  449
Medium chain triglycerides Feb 19, 2014 At the notifier's request, FDA ceased to evaluate this notice
  444
Milk protein concentrate and milk protein isolate Mar 18, 2013 At the notifier's request, FDA ceased to evaluate this notice
  504
  443
Shrimp-derived chitosan
   (Resubmission of GRN 170)
Feb 11, 2013 At the notifier's request, FDA ceased to evaluate this notice
  442
Volatile oil of mustard (white) Jan 3, 2013 At the notifier's request, FDA ceased to evaluate this notice
  439
Iron complex of tartaric acid Nov 9, 2012 At the notifier's request, FDA ceased to evaluate this notice
  434
Dried aqueous extract derived from white kidney bean (Phaseolus vulgaris) Oct 10, 2012 At the notifier's request, FDA ceased to evaluate this notice
  480
  433
Poloxamer fatty acid esters Aug 3, 2012 At the notifier's request, FDA ceased to evaluate this notice
  431
Colostral whey protein concentrate Oct 12, 2012 At the notifier's request, FDA ceased to evaluate this notice
  426
Rice hull fiber May 29, 2012 At the notifier's request, FDA ceased to evaluate this notice
  423
Cow's milk-derived lactoferrin May 2, 2012 At the notifier's request, FDA ceased to evaluate this notice
  416
Lutein diacetate Mar 20, 2012 At the notifier's request, FDA ceased to evaluate this notice
  432
  409
Lactobacillus reuteri strain NCIMB 30242 Jan 10, 2012 At the notifier's request, FDA ceased to evaluate this notice
  396
Chlorella vulgaris strain Beij Jul 5, 2012 At the notifier's request, FDA ceased to evaluate this notice
  391
Spirulina (Arthrospira platensis) Oct 6, 2011 At the notifier's request, FDA ceased to evaluate this notice
  370
Xylooligosaccharide Mar 28, 2011 At the notifier's request, FDA ceased to evaluate this notice
  368
Corn hull fiber Apr 6, 2011 At the notifier's request, FDA ceased to evaluate this notice
  366
Oat hull fiber Apr 6, 2011 At the notifier's request, FDA ceased to evaluate this notice
  364
Bacteriophages LAND12, OLB1, TSRW1, DSMP1, DP1 Mar 16, 2011 At the notifier's request, FDA ceased to evaluate this notice
  362
Levocarnitine Mar 9, 2011 At the notifier's request, FDA ceased to evaluate this notice
  361
1,4-α-D-glucan branching enzyme preparation Jan 31, 2011 At the notifier's request, FDA ceased to evaluate this notice
  358
Cyclic dextrin, highly branched Feb 1, 2011 At the notifier's request, FDA ceased to evaluate this notice
  356
Haematococcus pluvialis extract containing astaxanthin esters Nov 15, 2010 At the notifier's request, FDA ceased to evaluate this notice
  347
Caffeine Nov 24, 2010 At the notifier's request, FDA ceased to evaluate this notice
  346
Freeze-dried fruit gac powder Sep 10, 2010 At the notifier's request, FDA ceased to evaluate this notice
  340
Theobromine Nov 10, 2010 At the notifier's request, FDA ceased to evaluate this notice
  331
Algal oil (Chlorella protothecoides) Jun 1, 2010 At the notifier's request, FDA ceased to evaluate this notice
  330
Algal flour (Chlorella protothecoides) Jun 1, 2010 At the notifier's request, FDA ceased to evaluate this notice
  324
Heat-killed Lactobacillus plantarum Jul 7, 2010 At the notifier's request, FDA ceased to evaluate this notice
  322
Aqueous extract of Emblica officinalis
   (Resubmission of GRN 295)
Jun 16, 2010 At the notifier's request, FDA ceased to evaluate this notice
  483
  299
Lycopene from Escherichia coli expressing lycopene biosynthetic enzymes Sep 22, 2009 At the notifier's request, FDA ceased to evaluate this notice
  298
Silicon dioxide Oct 9, 2009 At the notifier's request, FDA ceased to evaluate this notice
  321
  295
Aqueous extract of Emblica officinalis Nov 23, 2009 At the notifier's request, FDA ceased to evaluate this notice
  322
  289
Colicin E1 purified from Escherichia coli Jun 25, 2009 At the notifier's request, FDA ceased to evaluate this notice
  276
Dunaliella bardawil alga Mar 6, 2009 At the notifier's request, FDA ceased to evaluate this notice
  351
  264
Sweet lupin flour Dec 16, 2008 At the notifier's request, FDA ceased to evaluate this notice
  263
Sweet lupin fiber Dec 16, 2008 At the notifier's request, FDA ceased to evaluate this notice
  262
Sweet lupin protein Dec 16, 2008 At the notifier's request, FDA ceased to evaluate this notice
  259
Catechins from green tea extract
   (Resubmission of GRN 225)
Aug 21, 2009 At the notifier's request, FDA ceased to evaluate this notice
  257
gamma-Amino butyric acid Dec 22, 2008 At the notifier's request, FDA ceased to evaluate this notice
  245
Menaquinone-7 Jun 2, 2008 At the notifier's request, FDA ceased to evaluate this notice
  244
Glutathione May 9, 2008 At the notifier's request, FDA ceased to evaluate this notice
  293
  241
High-selenium yeast Apr 9, 2008 At the notifier's request, FDA ceased to evaluate this notice
  260
  235
Human lactoferrin purified from rice Mar 12, 2010 At the notifier's request, FDA ceased to evaluate this notice
  234
Bovine globulin
   (Resubmission of GRN 169)
Feb 14, 2008 At the notifier's request, FDA ceased to evaluate this notice
  255
  225
Catechins from green tea extract Nov 26, 2007 At the notifier's request, FDA ceased to evaluate this notice
  259
  224
trans-Resveratrol Aug 1, 2007 At the notifier's request, FDA ceased to evaluate this notice
  203
Erythritol fatty acid esters Nov 15, 2006 At the notifier's request, FDA ceased to evaluate this notice
  297
  191
Human lysozyme purified from rice Mar 12, 2010 At the notifier's request, FDA ceased to evaluate this notice
  190
Hydroxypropyl methylcellulose Apr 6, 2006 At the notifier's request, FDA ceased to evaluate this notice
  213
  189
Lactoferrin (human) purified from bovine milk Dec 10, 2009 At the notifier's request, FDA ceased to evaluate this notice
  188
Carbon monoxide Nov 5, 2008 At the notifier's request, FDA ceased to evaluate this notice
  174
Lysozyme (human) enzyme preparation from rice Sep 13, 2005 At the notifier's request, FDA ceased to evaluate this notice
  172
Isomalto-oligosaccharide Oct 17, 2005 At the notifier's request, FDA ceased to evaluate this notice
  246
  170
Shrimp-derived chitosan Oct 31, 2005 At the notifier's request, FDA ceased to evaluate this notice
  443
  169
Bovine globulin Jul 19, 2005 At the notifier's request, FDA ceased to evaluate this notice
  234
  166
Carbon monoxide Sep 29, 2005 At the notifier's request, FDA ceased to evaluate this notice
  162
Lactoferrin (human) purified from rice Nov 16, 2006 At the notifier's request, FDA ceased to evaluate this notice
  160
Micro-algal oil (Ulkenia sp.) Apr 1, 2005 At the notifier's request, FDA ceased to evaluate this notice
  319
  153
Conjugated linoleic acid Aug 16, 2004 At the notifier's request, FDA ceased to evaluate this notice
  232
  150
Glucosamine hydrochloride prepared from chitin obtained from Aspergillus niger Sep 9, 2004 At the notifier's request, FDA ceased to evaluate this notice
  148
Vegetable oil conjugated linoleic acid preparation Aug 31, 2004 At the notifier's request, FDA ceased to evaluate this notice
  232
  139
Cassia gum
   (Resubmission of GRN 51)
May 3, 2004 At the notifier's request, FDA ceased to evaluate this notice
  107
Polydextrose Oct 17, 2002 At the notifier's request, FDA ceased to evaluate this notice
  101
Spirulina May 28, 2002 At the notifier's request, FDA ceased to evaluate this notice
  127
  98
Small planktivorous pelagic fish body oil Mar 25, 2002 At the notifier's request, FDA ceased to evaluate this notice
  102
  97
Tuna oil Jun 24, 2002 At the notifier's request, FDA ceased to evaluate this notice
  109
  73
Shrimp-derived chitosan Jan 31, 2002 At the notifier's request, FDA ceased to evaluate this notice
  59
Hydrogenated starch hydrolysate Sep 24, 2001 At the notifier's request, FDA ceased to evaluate this notice
  58
Gum arabic Sep 10, 2001 At the notifier's request, FDA ceased to evaluate this notice
  51
Cassia gum from Cassia tora/obtusifolia Feb 27, 2001 At the notifier's request, FDA ceased to evaluate this notice
  139
  36
Chromium picolinate; Ginkgo biloba leaf extract; and Ginseng extract Apr 10, 2000 At the notifier's request, FDA ceased to evaluate this notice
  31
Cetylpyridinium chloride Jan 10, 2000 At the notifier's request, FDA ceased to evaluate this notice
  38
  23
Protein preparation from animal blood Aug 2, 1999 At the notifier's request, FDA ceased to evaluate this notice
  17
Arabinogalactan Apr 11, 2000 At the notifier's request, FDA ceased to evaluate this notice
  47
  16
Menhaden oil Jun 8, 1999 At the notifier's request, FDA ceased to evaluate this notice
  12
Mesquite wood alcoholic extract Mar 11, 1999 At the notifier's request, FDA ceased to evaluate this notice
  18
  5
Tasteless smoke Nov 9, 1998 At the notifier's request, FDA ceased to evaluate this notice
  15
  1
Soy isoflavone extract Nov 3, 1998 At the notifier's request, FDA ceased to evaluate this notice

GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
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