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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.

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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 1108 Show All Page 1 of 23
(sorted Z-A)
Substance Date of closure FDA's Letter
1108 Lactiplantibacillus plantarum strain MCC 0537 Pending
1107 Bifidobacterium longum subsp. infantis strain LMG 11588 Pending
1106 Rebaudioside I obtained by enzymatic treatment of steviol glycosides purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside I) Pending
1105 Polyglycerol polyricinoleic acid Pending
1104 Egg-white protein produced by Komagataella phaffii strain ATCC GSD-1235 Pending
1103 Canola protein isolate Pending
1102 Invertase enzyme preparation produced by Trichoderma reesei expressing a gene for invertase from Aspergillus niger Pending
1101 Dried biomass of Chlamydomonas reinhardtii strain TAI114 Pending
1100 Fractionated whey protein concentrate containing 41% alpha-lactalbumin Pending
1099 3-fucosyllactose Pending
1098 Chickpea protein concentrate Pending
1097 Maltogenic alpha-amylase enzyme preparation produced by Escherichia coli expressing a gene encoding a maltogenic alpha-amylase from Geobacillus stearothermophilus Pending
1096 Saccharomyces cerevisiae strain OYR-243 Pending
1095 Bacillus subtilis strain ATCC AAN000002 spore preparation Pending
1094 Saccharomyces cerevisiae strain BY-989 expressing a gene encoding a carbon-sulfur lyase from Citrobacter freundii Pending
1093 Lacticaseibacillus rhamnosus IDCC 3201 Pending
1092 Bifidobacterium animalis subsp. lactis IDCC 4301 Pending
1091 2'-fucosyllactose Pending
1090 Bifidobacterium bifidum strain NITE BP-31 Pending
1089 Lactobacillus gasseri strain NCIMB 30370 Pending
1088 Lactococcus lactis strain KCTC 11865BP Pending
1087 Streptococcus thermophilus strain KCTC 11870BP Pending
1086 Lactobacillus plantarum strain KCTC 10782BP Pending
1085 Lactobacillus casei strain KCTC 12398BP Pending
1084 Lactobacillus rhamnosus CBT LR5 Pending
1083 Lactobacillus acidophilus CBT LA1 Pending
1082 Bifidobacterium lactis strain KCTC 11904BP Pending
1081 Bifidobacterium infantis strain KCTC 11859BP Pending
1080 Bifidobacterium breve strain KCTC 12201BP Pending
1079 Bifidobacterium longum strain KCTC 12200BP Pending
1078 Bifidobacterium bifidum strain KCTC 12199BP Pending
1077 Oat polar lipid extract Pending
1076 Galacto-oligosaccharides Mar 2, 2023 FDA has no questions (in PDF) (245 kB)
1075 6'-sialyllactose sodium salt Mar 22, 2023 FDA has no questions (in PDF) (286 kB)
1074 3'-sialyllactose sodium salt Pending
1073 Corn bran arabinoxylan Pending
1072 Lemnaceae fiber Pending
1071 Glucose oxidase enzyme preparation produced by Saccharomyces cerevisiae expressing a gene encoding a glucose oxidase from Aspergillus niger Pending
1070 Preparations containing six bacteriophages (phage) specific to Salmonella enterica Pending
1069 Corn protein Pending
1068 Lacto-N-tetraose Pending
1067 Lacto-N-neotetraose Apr 4, 2023 FDA has no questions (in PDF) (306 kB)
1066 Carnobacterium divergens strain M35 Pending
1065 Anaerobutyricum soehngenii CH106 Pending
1064 Pomegranate extract Pending
1063 Weissella cibaria CMU Pending
1062 Saccharomyces cerevisiae strain OYR-185 Pending
1061 Deactivated alkaline serine protease produced by Bacillus licheniformis strain CICC 10266 Pending
1060 2'-fucosyllactose Apr 4, 2023 FDA has no questions (in PDF) (333 kB)
1059 Lacto-N-neotetraose Dec 2, 2022 FDA has no questions (in PDF) (288 kB)

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(sorted Z-A)
Substance Date of closure FDA's Letter