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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.

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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 937 Show All Page 1 of 19
(sorted Z-A)
Substance Date of closure FDA's Letter
937 Staphylococcus carnosus DSM 25010 Pending
936 Leuconostoc carnosum DSM 32756 Pending
935 L-carnitine-L-tartrate Pending
934 Algal oil (<35% docosahexanoic acid) derived from Schizochytrium sp. strain CABIO-A-2 Pending
933 Algal oil (≥36% docosahexaenoic acid) from Schizochytrium sp. strain DHF Pending
932 2′-fucosyllactose Pending
931 Creatine monohydrate Pending
930 Silk fibroin derived from Bombyx mori cocoons Pending
929 2′-fucosyllactose Pending
928 Dried Saccharomyces cerevisiae yeast fermentate Pending
927 Polyvinyl alcohol Pending
926 Soluble rice flour Pending
925 3'-fucosyllactose Pending
924 2'-fucosyllactose Pending
923 Lacto-N-tetraose Pending
922 6'-sialyllactose sodium salt Pending
921 3'-sialyllactose sodium salt Pending
920 Thaumatin II Pending
919 Lacto-N-neotetraose Pending
918 Partially defatted almond protein flour Pending
917 Preparation containing three bacterial phages specific to Salmonella Pending
916 Dihydroquercetin Pending
915 Calcium L-methylfolate Pending
914 Alpha-linolenic acid diacylglycerol Pending
913 Algal oil (minimum 35% DHA) Pending
912 Trehalose Pending
911 Rebaudioside I Pending
910 Thaumatin II Pending
909 Whey protein containing 41% alpha-lactalbumin Pending
908 Lipase from Penicillium camemberti Pending
907 Wheat seed oil Aug 21, 2020 FDA has no questions (in PDF) (593 kB)
906 Wheat seed polar lipids Aug 24, 2020 FDA has no questions (in PDF) (573 kB)
905 Bacillus subtilis SG188 Jun 8, 2020 FDA has no questions (in PDF) (659 kB)
904 Fungal protein from fermented Fusarium sp. mycelia Pending
903 Quillaia extract type 2 Pending
902 Neohesperidin dihydrochalcone Pending
901 Glucosyl hesperidin Pending
900 Corn oil Pending
899 Citric acid esters of mono- and diglycerides Pending
898 Dried milk fat Pending
897 2-O-fucosyllactose Jun 12, 2020 FDA has no questions (in PDF) (715 kB)
896 Alpha-galacto-oligosaccharides Pending
895 Lacto-N-neotetraose Pending
894 White mulberry leaf extract Pending
893 D-psicose Jun 5, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (58 kB)
892 Refined shea butter Pending
891 Cellulase produced by Trichoderma reesei Pending
890 Corn oil derived from distillers grains Pending
889 Spermidine rich wheat germ extract Pending
888 Preparation containing three bacterial phages specific to Salmonella Feb 28, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (36 KB)

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(sorted Z-A)
Substance Date of closure FDA's Letter