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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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Records Found: 1068 Show All Page 2 of 22
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
1018 Carbon monoxide Pending
1017 Lacto-N-tetraose Pending
1016 6’-sialyllactose sodium salt Jul 15, 2022 FDA has no questions (in PDF) (237 kB)
1015 3’-sialyllactose sodium salt Jul 15, 2022 FDA has no questions (in PDF) (234 kB)
1014 2’-fucosyllactose Jul 15, 2022 FDA has no questions (in PDF) (295 kB)
1013 Lactobacillus rhamnosus DSM 33156 Dec 15, 2021 FDA has no questions (in PDF) (310 kB)
1012 Powdered sap from Angelica keiskei (ashitaba) containing 8% chalcones (ashitaba sap) Apr 7, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (108 kB)
1011 Alpha-amylase enzyme preparation produced by Bacillus subtilis strain AR-651 expressing the gene encoding alpha-amylase from Thermoactinomyces vulgaris Jul 18, 2022 FDA has no questions (in PDF) (323 kB)
1010 Rebaudioside M obtained by enzymatic treatment of steviol glycosides purified from the leaves of Stevia rebaudiana (Bertoni) Jan 26, 2022 FDA has no questions (in PDF) (412 kB)
1009 Water-soluble palm fruit extract Jun 24, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (129 kB)
1008 Algal oil (≥45% docosahexaenoic acid) from Aurantiochytrium limacinum TKD-1 Feb 25, 2022 FDA has no questions (in PDF) (166 kB)
1007 Bacillus subtilis strain R0179 Pending
1006 Short-chain fructooligosaccharides Jan 19, 2022 FDA has no questions (in PDF) (177 kB)
1005 β-Lactoglobulin from cow milk Mar 3, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF)
1004 Maltosyltrehalose syrup Jan 20, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (84 kB)
1003 Bifidobacterium longum subsp. infantis M-63 Apr 26, 2022 FDA has no questions (in PDF) (75 kB)
1002 Bifidobacterium breve strain MCC1274 Jul 22, 2022 FDA has no questions (in PDF) (221 kB)
1001 Myoglobin preparation from a strain of Pichia pastoris expressing the myoglobin gene from Bos taurus Dec 3, 2021 FDA has no questions (in PDF) (375 kB)
1000 Phycocyanin-rich extract of Galdieria sulphuraria (G. sulphuraria strain “FCC3424”) Mar 8, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (160 kB)
999 Enzyme-modified steviol glycosides Dec 3, 2021 FDA has no questions (in PDF) (172 kB)
998 Corn bran arabinoxylan Oct 25, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (101 kB)
997 Chitosan and beta-1,3-glucans from white button mushrooms (Agaricus bisporus) Feb 28, 2022 FDA has no questions (in PDF) (140 kB)
996 Synthetic amorphous silica Feb 4, 2022 FDA has no questions (in PDF) (137 kB)
995 β-glucans from Antrodia cinnamomea strain ATCC 200183 Jun 14, 2022 FDA has no questions (in PDF) (162 kB)
994 Miracle fruit (Synsepalum dulcificum), in pulp, powder, or protein forms Oct 26, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (140 kB)
993 L-carnitine-L-tartrate Oct 18, 2021 FDA has no questions (in PDF) (149 kB)
992 White mulberry (Morus alba Linn) leaf extract May 6, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (97 kB)
991 Chitonase enzyme preparation produced by Bacillus subtilis Pending
990 Short-chain fructooligosaccharides Oct 8, 2021 FDA has no questions (in PDF) (109 kB)
989 Bacillus subtilis expressing a modified gene encoding a variant of the wild-type subtilisin from B. clausii Pending
988 Lactobacillus fermentum LfQi6 Mar 28, 2022 FDA has no questions (in PDF) (138 kB)
987 2'-fucosyllactose Feb 2, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (236 kB)
986 Chlorella sorokiniana powder and C. sorokiniana micro powder Dec 21, 2021 FDA has no questions (in PDF) (148 kB)
985 Bifidobacterium longum subsp. infantis strain ATCC SD 6720 Dec 21, 2021 FDA has no questions (in PDF) (339 kB)
984 Wolffia globosa Oct 8, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (429 kB)
983 Purified steviol glycosides from the leaves of Stevia rebaudiana (Bertoni) Jun 28, 2021 FDA has no questions (in PDF) (202 kB)
982 Polygalacturonase enzyme preparation produced by Aspergillus oryzae expressing a polygalacturonase gene from A. tubingensis Mosseray Feb 2, 2022 FDA has no questions (in PDF) (154 kB)
981 Sterol esterase enzyme preparation produced by Trichoderma reesei expressing a gene encoding sterol esterase from Melanocarpus albomyces Pending
980 Dry whole milk Jul 13, 2021 FDA has no questions (in PDF) (124 kB)
979 Pectin esterase enzyme preparation produced by Aspergillus oryzae expressing a pectin esterase gene from A. tubingensis Oct 18, 2021 FDA has no questions (in PDF) (140 kB)
978 Hydrolyzed aqueous olive pulp extract Dec 10, 2021 FDA has no questions (in PDF) (256 kB)
977 D-tagatose produced via novel enzymatic cascade Oct 21, 2021 FDA has no questions (in PDF) (153 kB)
976 Sodium hyaluronate May 24, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (185 kB)
975 Maltogenic alpha-amylase enzyme preparation produced by Bacillus licheniformis carrying the gene coding for maltogenic alpha-amylase from Geobacillus stearothermophilus Jul 8, 2021 FDA has no questions (in PDF) (313 kB)
974 Maltogenic alpha-amylase enzyme preparation produced by Bacillus subtilis Feb 2, 2022 FDA has no questions (in PDF) (310 kB)
973 Maple wood fiber May 13, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (169 kB)
972 Pectin hydrolysate from carrot pomace Mar 25, 2022 FDA has no questions (124 kB)
971 Bacillus clausii strain 088AE spore preparation Mar 3, 2022 FDA has no questions (in PDF) (150 kB)
970 Enzyme-modified steviol glycosides Apr 9, 2021 FDA has no questions (in PDF) (225 kB)
969 Bacillus subtilis “Bss-19” spore preparation Oct 6, 2021 FDA has no questions (in PDF)

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GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

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