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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 1077 Show All Page 17 of 22
GRN No. Substance
(sorted A-Z)
Date of closure FDA's Letter
107 Polydextrose Oct 17, 2002 At notifier's request, FDA ceased to evaluate the notice
982 Polygalacturonase enzyme preparation produced by Aspergillus oryzae expressing a polygalacturonase gene from A. tubingensis Mosseray Feb 2, 2022 FDA has no questions (in PDF) (154 kB)
557 Polygalacturonase from Aspergillus tubingensis expressed in Trichoderma reesei Jul 23, 2015 FDA has no questions
339 Polyglutamic acid Nov 6, 2010 FDA has no questions
269 Polyglycerol fatty acid esters with a degree of polymerization of 11 to 40 for the polyglycerol backbone May 21, 2009 FDA has no questions
266 Polyglycerol polyricinoleate May 29, 2009 FDA has no questions
466 Polyglycerol polyricinoleic acid Sep 25, 2013 FDA has no questions
270 Polyglycerol polyricinoleic acid Jun 15, 2009 FDA has no questions
179 Polyglycerol polyricinoleic acid Jan 20, 2006 FDA has no questions
9 Polyglycerol polyricinoleic acid Mar 2, 1999 FDA has no questions
202 Polyoxyethanyl-alpha-tocopheryl sebacate (PTS) Dec 6, 2006 FDA has no questions
497 Polyphenols from the fruit of Litchi chinensis Sonn. and from leaves of Camellia sinensis (L.) Sinensis Jun 12, 2014 FDA has no questions; some uses may require a color additive listing
407 Polysaccharide complex of konjac glucomannan (konjac), sodium alginate, and xanthan gum (polysaccharide complex KAX) Apr 10, 2012 FDA has no questions
328 Polysaccharide complex of konjac glucomannan (konjac), sodium alginate, and xanthan gum (polysaccharide complex KAX) May 20, 2011 Notice does not provide a basis for a GRAS determination.
927 Polyvinyl alcohol Feb 26, 2021 FDA has no questions (in PDF) (206 kB)
767 Polyvinyl alcohol Sep 7, 2018 FDA has no questions (in PDF) (57 kB)
141 Polyvinyl alcohol Apr 28, 2004 FDA has no questions
1058 Polyvinyl alcohol Pending
1064 Pomegranate extract Pending
21 Pork collagen Jul 29, 1999 FDA has no questions
314 Pork protein Aug 11, 2010 FDA has no questions
60 Potassium bisulfate Jan 19, 2001 FDA has no questions
770 Potassium polyaspartate Sep 11, 2018 FDA has no questions (in PDF) (789 kB)
538 Potassium-rich extract from Saccharum officinarum L. (sugarcane) Apr 19, 2015 FDA has no questions
310 Potato fiber Jun 10, 2010 FDA has no questions
447 Potato protein isolates May 24, 2013 FDA has no questions (additional correspondence available)
168 Poultry protein Nov 18, 2005 FDA has no questions
829 Powdered Aspergillus oryzae grown with one or more added minerals Dec 9, 2019 FDA has no questions (in PDF) (110 KB)
1012 Powdered sap from Angelica keiskei (ashitaba) containing 8% chalcones (ashitaba sap) Apr 7, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (108 kB)
435 Preparation consisting of six bacterial monophage specific to Salmonella enterica (monophage cocktail) Feb 22, 2013 FDA has no questions (additional correspondence available)
834 Preparation containing bacterial phages specific to shiga-toxin producing Escherichia coli Nov 8, 2019 FDA has no questions (in PDF) (91 kB)
672 Preparation containing five bacterial monophages specific to Shigella spp. Mar 27, 2017 FDA has no questions (in PDF) (109 kB)
528 Preparation containing six bacterial monophages (LIST-36, LMSP-25, LMTA-34, LMTA-57, LMTA-94 and LMTA-148) specific to Listeria monocytogenes Dec 23, 2014 FDA has no questions
724 Preparation containing six bacterial phages specific to shiga-toxin producing Escherichia coli Apr 10, 2018 FDA has no questions (in PDF) (75 kB)
1038 Preparation containing six bacteriophages (phage) specific to Salmonella enterica spp. serovars Pending
603 Preparation containing the bacterial monophages, BP-63 and BP-12, specific to Salmonella Jul 28, 2016 FDA has no questions
752 Preparation containing the bacterial monophages, BP-63 and LVR16-A, specific to Salmonella Jul 13, 2018 FDA has no questions (in PDF) (57 kB)
630 Preparation containing the bacterial monophages, Fo1a and S16, specific to Salmonella May 17, 2016 At the notifier's request, FDA ceased to evaluate this notice
468 Preparation containing the bacterial monophages, Fo1a and S16, specific to Salmonella Dec 23, 2013 FDA has no questions (additional correspondence available)
917 Preparation containing three bacterial phages specific to Salmonella Sep 10, 2020 FDA has no questions (in PDF) (540 kB)
888 Preparation containing three bacterial phages specific to Salmonella Feb 28, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (36 KB)
827 Preparation containing three bacterial phages specific to several Escherichia coli serotypes Aug 12, 2019 FDA has no questions (in PDF) (76 KB)
757 Preparation containing two bacterial phages specific to Escherichia coli O157 Aug 3, 2018 FDA has no questions (in PDF) (67 kB)
399 Preparation of Bacillus coagulans strain GBI-30, 6086 spores Jul 31, 2012 FDA has no questions
1070 Preparations containing six bacteriophages (phage) specific to Salmonella enterica Pending
966 Preparations containing three to eight bacteriophages specific to Campylobacter jejuni Oct 6, 2021 FDA has no questions (in PDF) (312 kB)
564 Protease from Bacillus licheniformis Jul 7, 2015 FDA has no questions
563 Protease from Fusarium venenatum Jul 8, 2015 FDA has no questions
1020 Protein from Helianthus annuus (sunflower protein) Jun 14, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (101 kB)
267 Protein glutaminase enzyme preparation derived from Chryseobacterium proteolyticum Jul 15, 2009 FDA has no questions

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GRN No. Substance
(sorted A-Z)
Date of closure FDA's Letter
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