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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 1041 Show All Page 17 of 21
GRN No. Substance
(sorted A-Z)
Date of closure FDA's Letter
1038 Preparation containing six bacteriophages (phage) specific to Salmonella enterica spp. serovars Pending
603 Preparation containing the bacterial monophages, BP-63 and BP-12, specific to Salmonella Jul 28, 2016 FDA has no questions
752 Preparation containing the bacterial monophages, BP-63 and LVR16-A, specific to Salmonella Jul 13, 2018 FDA has no questions (in PDF) (57 kB)
630 Preparation containing the bacterial monophages, Fo1a and S16, specific to Salmonella May 17, 2016 At the notifier's request, FDA ceased to evaluate this notice
468 Preparation containing the bacterial monophages, Fo1a and S16, specific to Salmonella Dec 23, 2013 FDA has no questions (additional correspondence available)
917 Preparation containing three bacterial phages specific to Salmonella Sep 10, 2020 FDA has no questions (in PDF) (540 kB)
888 Preparation containing three bacterial phages specific to Salmonella Feb 28, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (36 KB)
827 Preparation containing three bacterial phages specific to several Escherichia coli serotypes Aug 12, 2019 FDA has no questions (in PDF) (76 KB)
757 Preparation containing two bacterial phages specific to Escherichia coli O157 Aug 3, 2018 FDA has no questions (in PDF) (67 kB)
399 Preparation of Bacillus coagulans strain GBI-30, 6086 spores Jul 31, 2012 FDA has no questions
966 Preparations containing three to eight bacteriophages specific to Campylobacter jejuni Oct 6, 2021 FDA has no questions (in PDF) (312 kB)
564 Protease from Bacillus licheniformis Jul 7, 2015 FDA has no questions
563 Protease from Fusarium venenatum Jul 8, 2015 FDA has no questions
1020 Protein from Helianthus annuus (sunflower protein) Pending
267 Protein glutaminase enzyme preparation derived from Chryseobacterium proteolyticum Jul 15, 2009 FDA has no questions
23 Protein preparation from animal blood Aug 2, 1999 At notifier's request, FDA ceased to evaluate the notice
498 Psicose Jun 12, 2014 FDA has no questions
99 Pullulan Aug 1, 2002 FDA has no questions
72 Pullulanase derived from Bacillus licheniformis carrying a gene encoding pullulanase from B. deramificans Jun 12, 2001 FDA has no questions
20 Pullulanase derived from Bacillus subtilis carrying a gene encoding pullulanase from Bacillus naganoensis Sep 30, 1999 FDA has no questions
205 Pullulanase enzyme preparation from Bacillus subtilis expressing the pullulanase gene from B. acidopullulyticus Dec 4, 2006 FDA has no questions
645 Pullulanase from Bacillus deramificans and Bacillus acidopullulyticus expressed in Bacillus licheniformis Nov 1, 2016 FDA has no questions
861 Pullulanase from Bacillus deramificans produced in Bacillus subtilis Jul 21, 2020 FDA has no questions (in PDF) (605 kB)
618 Purified seawater May 27, 2016 FDA has no questions
839 Purified steviol glycosides Jul 8, 2019 FDA has no questions (in PDF) (77 KB)
838 Purified steviol glycosides Jul 12, 2019 FDA has no questions (in PDF) (83 KB)
795 Purified steviol glycosides Sep 25, 2018 FDA has no questions (in PDF) (105 kB)
733 Purified steviol glycosides Jan 9, 2018 FDA has no questions (in PDF) (69 kB)
702 Purified steviol glycosides Sep 28, 2017 FDA has no questions (in PDF) (65 kB)
619 Purified steviol glycosides May 27, 2016 FDA has no questions
983 Purified steviol glycosides from the leaves of Stevia rebaudiana (Bertoni) Jun 28, 2021 FDA has no questions (in PDF) (202 kB)
367 Purified steviol glycosides with rebaudioside A and stevioside as the principal components Jul 8, 2011 FDA has no questions
349 Purified steviol glycosides with rebaudioside A and stevioside as the principal components Jul 14, 2011 FDA has no questions
323 Purified steviol glycosides with rebaudioside A and stevioside as the principal components Jul 9, 2010 FDA has no questions (additional correspondence available)
304 Purified steviol glycosides with rebaudioside A and stevioside as the principal components Mar 22, 2010 FDA has no questions
287 Purified steviol glycosides with rebaudioside A and stevioside as the principal components Aug 28, 2009 FDA has no questions
275 Purified steviol glycosides with rebaudioside A as the principal component Jun 11, 2009 FDA has no questions
473 Purified steviol glycosides with rebaudioside X as the principal component Dec 17, 2013 FDA has no questions
590 Pyrroloquinoline quinone Jan 18, 2016 At the notifier's request, FDA ceased to evaluate this notice
709 Pyrroloquinoline quinone disodium salt Mar 6, 2018 FDA has no questions (in PDF) (79 kB)
701 Pyrroloquinoline quinone disodium salt Sep 8, 2017 FDA has no questions (in PDF) (68 kB)
641 Pyrroloquinoline quinone disodium salt Oct 14, 2016 FDA has no questions
625 Pyrroloquinoline quinone disodium salt Aug 18, 2016 FDA has no questions
694 Pyrroloquinoline quinone disodium salt (PQQ) Sep 28, 2017 FDA has no questions (in PDF) (72 kB)
341 Quercetin Nov 22, 2010 FDA has no questions; some uses may require a color additive listing
165 Quillaia extract type 1 Nov 9, 2005 FDA has no questions
903 Quillaia extract type 2 Apr 21, 2021 FDA has no questions (in PDF) (195 kB)
692 Quinoa sprout extract Nov 3, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (33 kB)
787 Quinoa sprout powder Sep 9, 2018 FDA has no questions (in PDF) (94 kB)
632 Rebaudioside A from Yarrowia lipolytica Jun 24, 2016 FDA has no questions

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GRN No. Substance
(sorted A-Z)
Date of closure FDA's Letter

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