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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.

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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 1011 Show All Page 1 of 21
(sorted Z-A)
Substance Date of closure FDA's Letter
1011 Alpha-amylase enzyme preparation produced by Bacillus subtilis strain AR-651 expressing the gene encoding alpha-amylase from Thermoactinomyces vulgaris Pending
1010 Rebaudioside M obtained by enzymatic treatment of steviol glycosides purified from the leaves of Stevia rebaudiana (Bertoni) Pending
1009 Water-soluble palm fruit extract Pending
1008 Algal oil (≥35% docosahexaenoic acid) from Aurantiochytrium limacinum TKD-1 Pending
1007 Bacillus subtilis strain R0179 Pending
1006 Short-chain fructooligosaccharides Pending
1005 β-Lactoglobulin from cow milk Pending
1004 Maltosyltrehalose syrup Pending
1003 Bifidobacterium longum subsp. infantis M-63 Pending
1002 Bifidobacterium breve strain MCC1274 Pending
1001 Myoglobin preparation from a strain of Pichia pastoris expressing the myoglobin gene from Bos taurus Pending
1000 Phycocyanin-rich extract of Galdieria sulphuraria (G. sulphuraria strain “FCC3424”) Pending
999 Enzyme-modified steviol glycosides Pending
998 Corn bran arabinoxylan Pending
997 Chitosan and beta-1,3-glucans from white button mushrooms (Agaricus bisporus) Pending
996 Synthetic amorphous silica Pending
995 β-glucans from Antrodia cinnamomea strain ATCC 200183 Pending
994 Miracle fruit (Synsepalum dulcificum), in pulp, powder, or protein forms Pending
993 L-carnitine-L-tartrate Pending
992 White mulberry (Morus alba Linn) leaf extract Pending
991 Chitonase enzyme preparation produced by Bacillus subtilis Pending
990 Short-chain fructooligosaccharides Pending
989 Bacillus subtilis expressing a modified gene encoding a variant of the wild-type subtilisin from B. clausii Pending
988 Lactobacillus fermentum LfQi6 Pending
987 2'-fucosyllactose Pending
986 Chlorella sorokiniana powder and C. sorokiniana micro powder Pending
985 Bifidobacterium longum subsp. infantis strain ATCC SD 6720 Pending
984 Wolffia globosa Pending
983 Purified steviol glycosides from the leaves of Stevia rebaudiana (Bertoni) Pending
982 Polygalacturonase enzyme preparation produced by Aspergillus oryzae expressing a polygalacturonase gene from A. tubingensis Mosseray Pending
981 Sterol esterase enzyme preparation produced by Trichoderma reesei expressing a gene encoding sterol esterase from Melanocarpus albomyces Pending
980 Dry whole milk Jul 13, 2021 FDA has no questions (in PDF) (124 kB)
979 Pectin esterase enzyme preparation produced by Aspergillus oryzae expressing a pectin esterase gene from A. tubingensis Pending
978 Hydrolyzed aqueous olive pulp extract Pending
977 D-tagatose produced via novel enzymatic cascade Pending
976 Sodium hyaluronate Pending
975 Maltogenic alpha-amylase enzyme preparation produced by Bacillus licheniformis carrying the gene coding for maltogenic alpha-amylase from Geobacillus stearothermophilus Pending
974 Maltogenic alpha-amylase enzyme preparation produced by Bacillus subtilis Pending
973 Maple wood fiber May 13, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (169 kB)
972 Pectin hydrolysate from carrot pomace Pending
971 Bacillus clausii strain 088AE spore preparation Pending
970 Enzyme-modified steviol glycosides Pending
969 Bacillus subtilis “Bss-19” spore preparation Pending
968 Rebaudioside B Pending
967 Soluble egg-white protein produced by Komagataella phaffii strain GSD-1209 Sep 9, 2021 FDA has no questions (in PDF) (305 kB)
966 Preparations containing three to eight bacteriophages specific to Campylobacter jejuni Pending
965 Arabinase enzyme preparation produced by Aspergillus tubingensis Jul 20, 2021 FDA has no questions (in PDF) (500 kB)
964 Lysophospholipase enzyme preparation from Aspergillus niger produced by Trichoderma reesei Sep 9, 2021 FDA has no questions (in PDF) (158 kB)
963 Fungal oil (≥40% arachidonic acid) from Mortierella alpina Pending
962 Rice bran wax Pending

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(sorted Z-A)
Substance Date of closure FDA's Letter