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U.S. Department of Health and Human Services

Inventory of Food Contact Substances Listed in 21 CFR

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FDA authorizes Food Contact Substances by identity, intended use, and conditions of use; the presence of a substance in this list indicates that only certain intended uses and use conditions are authorized by FDA regulations. This list is a compilation of the names of these substances (or combinations of substances in the case of, for example, polymers and resins) found in 21 CFR parts 173, 175 - 178, 179.45, 180.22, 181, and 186. The regulation(s) cited for specific substances should always be consulted to understand the regulatory status of a given substance, its allowed intended uses and conditions of use.

The inventory also contains information on substances listed in 21 CFR 189 that are prohibited from use as food contact substances.

See more about Inventory of Food Contact Substances Listed in 21 CFR.

See also: Inventory of Effective Food Contact Substance (FCS) Notifications.

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  • To view the regulations authorizing the use of a given substance, select the corresponding link(s) in the 21 CFR column.
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Records Found: 141 Show 50 records at a time
CAS Reg. No.*
(or other ID)
Substance*
(sorted A-Z)
21 CFR*
86830-15-1 ACRYLIC ACID-POLYETHYLENE GLYCOL ALLYL ETHER COPOLYMER, SODIUM SALT 176.170
977044-88-4 ALPHA-ALKYL(C10-C14)-OMEGA-HYDROXYPOLY(OXYETHYLENE) POLY(OXYPROPYLENE) 178.1010
69227-21-0 ALPHA-ALKYL(C12-C18)-OMEGA-HYDROXYPOLY(OXYETHYLENE) POLY(OXYPROPYLENE) 178.1010
977100-87-0 ALPHA, ALPHA'-(METHYLENEBIS(4-(1,1,3,3-TETRAMETHYLBUTYL)-O-PHENYLENE))BIS(OMEGA-HYDROXYPOLY(OXYETHYLENE)) HAVING 6-7.5 MOLES OF ETHYLENE OXIDE PER HYDROXYL GROUP 176.210
176.300
977057-53-6 ALPHA-CIS-9-OCTADECENYL-OMEGA-HYDROXPOLY(OXYETHYLENE) (20 mol) 175.105
176.180
177.1210
178.3770
977138-17-2 AMMONIA/ETHYLENE DICHLORIDE/SODIUM HYDROXIDE POLYETHYLENEAMINE MIXTURE 176.170
9038-95-3 ALPHA-BUTYL-OMEGA-HYDROXYPOLY(OXYETHYLENE) POLY(OXYPROPYLENE) 173.310
173.340
175.105
177.1632
178.3570
178.3910
977039-31-8 COCONUT ALCOHOL, POLYETHYLENE GLYCOL, SODIUM SULFATE 177.2800
9040-38-4 DISODIUM PEG NONYLPHENYL ETHER SULFOSUCCINATE 175.105
178.3400
26401-47-8 ALPHA-(P-DODECYLPHENYL)-OMEGA-HYDROXYPOLY(OXYETHYLENE) 172.710
176.180
176.210
9003-11-6 ETHYLENE OXIDE/PROPYLENE OXIDE COPOLYMER 172.808
173.340
176.210
177.1210
177.1680
178.1010
178.3570
130328-24-4 N,N,N',N',N'',N''-HEXAKIS(METHOXYMETHYL)-1,3,5-TRIAZINE-2,4,6-TRIAMINE POLYMER 176.170
9043-30-5 ISOTRIDECYL ALCOHOL, ETHOXYLATED 178.3910
62362-49-6 MONO- AND BIS-(OCTADECYLDIETHYLENE OXIDE) PHOSPHATE 177.1200
977156-29-8 MONO- AND DI(2-ALKENYL(C15-21)SUCCINYL ESTERS OF POLYETHYLENE GLYCOL 176.180
26027-38-3 NONOXYNOL 175.105
176.180
176.210
977078-58-2 NONYLPHENOL POLYETHYLENE OXIDE (9-12 MOLES) 176.300
178.1010
31691-97-1 ALPHA-(P-NONYLPHENYL)-OMEGA-HYDROXYPOLY(OXYETHYLENE) SULFATE, AMMONIUM SALT 175.105
176.180
178.3400
977111-24-2 OCTYLPHENOL POLY(ETHYLENE OXIDE-CO-PROPYLENE OXIDE) (40 MOLES ETHYLENE OXIDE/25 MOLES PROPYLENE OXIDE) 176.300
5117-19-1 PEG-8 176.180
176.210
181.30
68002-97-1 PEG ALKYL(C10-16) ETHER 178.3910
9004-86-8 PEG DIBENZOATE 175.105
9005-02-1 PEG DILAURATE
9004-81-3 PEG LAURATE 178.3910
9002-92-0 PEG LAURYL ETHER 178.3760
9006-28-4 PEG (MW 200-600) ESTERS OF FATTY ACIDS 175.105
9004-96-0 PEG OLEATE 175.300
9004-98-2 PEG OLEYL ETHER 176.180
176.200
177.1210
178.3400
68551-13-3 PEG/PPG N-ALKYL ETHER, C12-15 178.1010
70802-40-3 PEG-8 STEARATE 176.170
176.200
177.1200
178.3910
9005-00-9 PEG STEARYL ETHER
24938-91-8 PEG TRIDECYL ETHER 175.105
176.200
64502-13-2 PHOSPHORIC ACID TRIESTERS WITH TRIETHYLENE GLYCOL 178.2010
114133-44-7 POLY(ADIPICACID-CO-N-(2-AMINOETHYL)-1,3-PROPANEDIAMINE-CO-N,N'-BIS(3-AMINOPROPYL)ETHYLENEDIAMINE-CO-EPICHLOROHYDRIN-CO-ETHYLENEDIAMINE-CO-ETHYLEN 176.180
167678-43-5 POLY(ADIPIC ACID-CO-N-(2-AMINOETHYL)-1,3-PROPANEDIAMINE-CO-N,N'-BIS(3-AMINOPROPYL)ETHYLENEDIAMINE-CO-EPICHLOROHYDRIN-CO-ETHYLENEDIAMINE-CO-ETHYLENIMINE-CO-PEG) 176.180
67893-53-2 POLY(ADIPIC ACID-CO-BUTYLENE GLYCOL-CO-ETHYLENE GLYCOL-TRMETHYLOLPROPANE) 175.105
175.300
177.1390
177.2420
115340-77-7 POLY(ADIPIC ACID-CO-DIETHYLENETRIAMINE-CO-EPICHLOROHYDRIN-CO-ETHYLENIMINE-CO-FORMIC ACID-CO-PEG) 176.180
167678-45-7 POLYAMIDOAMINE-ETHYLENEIMINE-EPICHLOROHYDRIN RESIN 176.170
25609-72-7 POLY(AZELAIC ACID-CO-ETHYLENE GLYCOL-CO-TEREPHTHALIC ACID) 175.320
177.1390
177.1630
9002-88-4 POLYETHYLENE (M W 2,000-21,000) 172.615
173.20
175.300
176.180
176.200
176.210
177.1200
177.1390
177.1395
177.1520
177.1615
177.1620
177.2210
177.2600
178.3570
178.38
977087-60-7 POLYETHYLENEAMINOSTEARAMIDE ETHYL SULFATE 177.1200
64754-90-1 POLYETHYLENE, CHLORINATED 177.1610
977101-15-7 POLYETHYLENE, CHLOROSULFONATED 177.2210
25038-36-2 POLY(ETHYLENE-CO-5-ETHYLIDENE-2-NORBORNENE-CO-PROPYLENE) 177.1200
177.1210
177.1520
177.2600
178.1005
61615-63-2 POLY(ETHYLENE-CO-FUMARIC ACID-CO-1,4-HEXADIENE-CO-PROPYLENE) 177.1520
25190-87-8 POLY(ETHYLENE-CO-1,4-HEXADIENE-CO-2,5-NORBORNADIENE-CO-PROPYLENE) 175.105
25038-37-3 POLY(ETHYLENE-CO-1,4-HEXADIENE-CO-PROPYLENE) 177.1200
177.1520
177.2600
178.1005
25213-02-9 POLY(ETHYLENE-CO-1-HEXENE) 175.105
177.1200
177.1390
177.1395
177.1520
178.1005
83833-97-0 POLY(ETHYLENE-CO-1-HEXENE-CO-1-OCTENE) 177.1200
177.1390
177.1395
177.1520
178.1005
25895-46-9 POLY(ETHYLENE-CO-1-HEXENE-CO-PROPYLENE) 175.105
177.1200
177.1350
177.1390
177.1395
177.1520
178.1005
25068-58-0 POLY(ETHYLENE-CO-ISOBUTYL ACRYLATE) 175.105
175.300
176.180
37433-35-5 POLY(ETHYLENE-CO-ISOBUTYL ACRYLATE-CO-METHACRYLIC ACID) 175.105
176.180
177.1330
178.1005
93228-27-4 POLY(ETHYLENE-CO-ISOBUTYL ACRYLATE-CO-METHACRYLIC ACID), POTASSIUM SALT 177.1330
178.1005
61615-65-4 POLY(ETHYLENE-CO-ISOBUTYL ACRYLATE-CO-METHACRYLIC ACID), SODIUM SALT 177.1330
178.1005
977107-96-2 POLY(ETHYLENE-CO-ISOBUTYL ACRYLATE-CO-METHACRYLIC ACID), SODIUM ZINC SALT 177.1330
178.1005
61843-71-8 POLY(ETHYLENE-CO-ISOBUTYL ACRYLATE-CO-METHACRYLIC ACID), ZINC SALT 177.1330
178.1005
25639-19-4 POLY(ETHYLENE-CO-ISOBUTYLENE) 175.105
176.180
177.1200
177.1390
177.1395
177.1520
178.1005
977119-42-8 POLY(ETHYLENE-CO-ISOOCTENE), LOW MW 177.1200
177.1390
177.1395
177.1520
178.1005
26713-14-4 POLY(ETHYLENE-CO-ITACONIC ACID) 175.105
176.180
9006-26-2 POLY(ETHYLENE-CO-MALEIC ANHYDRIDE) 175.105
176.170
177.1200
177.1210
177.1520
178.1005
28064-24-6 POLY(ETHYLENE-CO-MALEIC ANHYDRIDE-CO-VINYL ACETATE) 175.105
176.180
177.1350
977174-86-9 POLY(ETHYLENE-CO-METHACRYLATE) 175.105
176.180
25053-53-6 POLY(ETHYLENE-CO-METHACRYLIC ACID) 175.105
176.180
26375-31-5 POLY(ETHYLENE-CO-METHACRYLIC ACID-CO-VINYL ACETATE) 175.105
176.180
977115-19-7 POLY(ETHYLENE-CO-METHACRYLIC ACID-CO-VINYL ACETATE), POTASSIUM PARTIAL SALT 177.1330
178.1005
25034-77-9 POLY(ETHYLENE-CO-5-METHYLENE-2-NORBORNENE-CO-PROPYLENE) 177.1200
177.1210
177.1520
177.2600
178.1005
55973-33-6 POLY(ETHYLENE-CO-METHYL-5-NORBORNENE-2,3-DICARBOXYLIC ANHYDRIDE) 177.1200
177.1520
178.1005
25951-70-6 POLY(ETHYLENE-CO-N-METHYLOLACRYLAMIDE-CO-VINYL ACETATE) 175.105
176.170
176.180
25213-96-1 POLY(ETHYLENE-CO-4-METHYL-1-PENTENE) 177.1200
177.1390
177.1395
177.1520
178.1005
120792-37-2 POLY(ETHYLENE-CO-4-METHYL-1-PENTENE-CO-1-OCTENE) 177.1200
177.1390
177.1395
177.1520
178.1005
31548-02-4 POLY(ETHYLENE-CO-4-METHYL-1-PENTENE-CO-PROPYLENE) 177.1200
177.1390
177.1395
177.1520
178.1005
26221-73-8 POLY(ETHYLENE-CO-1-OCTENE) 175.105
177.1200
177.1390
177.1395
177.1520
178.1005
26587-28-0 POLY(ETHYLENE-CO-1-OCTENE-CO-PROPYLENE) 177.1200
177.1390
177.1395
177.1520
178.1005
26221-69-2 POLY(ETHYLENE-CO-PENTENE) 177.1200
177.1390
177.1395
177.1520
178.1005
9010-79-1 POLY(ETHYLENE-CO-PROPYLENE) 175.105
177.1200
177.1210
177.1390
177.1395
177.1520
177.2600
178.1005
114815-61-1 POLY(ETHYLENE-CO-2,4,4-TRIMETHYL-1-PENTENE) 177.1200
177.1390
177.1395
177.1520
178.1005
24937-78-8 POLY(ETHYLENE-CO-VINYL ACETATE) 175.105
175.300
176.180
177.1200
177.1210
177.1350
177.1390
178.1005
179.45
25085-46-5 POLY(ETHYLENE-CO-VINYL ACETATE-CO-VINYL CHLORIDE) 175.105
176.180
25067-34-9 POLY(ETHYLENE-CO-VINYL ALCOHOL) 175.105
25037-78-9 POLY(ETHYLENE-CO-VINYL CHLORIDE) 175.105
176.180
177.1950
178.2650
12624-35-0 POLY(ETHYLENEDIAMINE-CO-LINOLEIC ACID DIMER) 175.105
977149-41-9 POLYETHYLENE, FLUORINATED (SURFACE) 177.1615
25322-68-3 POLYETHYLENE GLYCOL (M W 200-9,500) 172.210
172.820
173.310
173.340
175.105
175.300
176.180
178.3750
73.1
977053-64-7 POLYETHYLENE GLYCOL 6000 177.2420
24938-37-2 POLY(ETHYLENE GLYCOL ADIPATE) 175.105
175.300
175.320
68954-91-6 POLYETHYLENE GLYCOL ALKYL(C10-C12) ETHER SULFOSUCCINATE, DISODIUM SALT 175.105
178.3400
53806-80-7 POLY(ETHYLENE GLYCOL BENZOATE) 175.105
175.300
68183-39-1 POLY(ETHYLENE GLYCOL-CO-GLYCEROL-CO-TRIMELLITIC ANHYDRIDE) 175.300
32441-30-8 POLY(ETHYLENE GLYCOL-CO-1,6-HEXANEDIOL-CO-TEREPHTHALIC ACID) 177.1390
26810-06-0 POLY(ETHYLENE GLYCOL-CO-ISOPHTHALIC ACID) 175.300
175.320
177.1390
177.2420
24938-04-3 POLY(ETHYLENE GLYCOL-CO-ISOPHTHALIC ACID-CO-TEREPHTHALIC ACID) 175.320
177.1390
177.1630
177.2420
178.1005
68608-84-4 POLY(ETHYLENE GLYCOL-CO-MALEIC ANHYDRIDE-CO-METHYL ROSINATE-CO-PHTHALIC ANHYDRIDE) 176.170
177.1200
25037-32-5 POLY(ETHYLENE GLYCOL-CO-SEBACIC ACID) 175.105
175.300
175.320
26679-04-9 POLY(ETHYLENE GLYCOL-CO-TEREPHTHALIC ACID-CO-TRIMETHYLOPROPANE) 175.300
175.320
177.1390
177.2420
55621-34-6 POLYETHYLENE GLYCOL (200) DILAURATE 176.170
176.180
176.200
25777-71-3 POLY(ETHYLENE GLYCOL DIMETHACRYLATE-CO-METHYL METHACRYLATE) 177.1010
977055-01-8 POLYETHYLENE GLYCOL (400) ESTERS OF COCONUT OIL FATTY ACIDS 175.300
176.170
176.180
176.200
176.210
177.1210
977068-27-1 POLYETHYLENE GLYCOL (600) ESTERS OF TALL OIL FATTY ACIDS 175.300
176.170
176.180
176.210
27496-67-9 POLY(ETHYLENE GLYCOL FUMARATE) 175.105
175.300
175.320
177.1390
177.2420
25949-13-7 POLY(ETHYLENE GLYCOL MALEATE) 175.105
175.300
177.1390
177.2420
150413-26-6 POLYETHYLENE GLYCOL MONO-ISOTRIDECYL ETHER SULFATE, SODIUM SALT 175.105
176.180
35179-86-3 POLYETHYLENE GLYCOL (400) MONOLAURATE 176.170
177.1200
178.3520
178.3760
977055-24-5 POLYETHYLENE GLYCOL (600) MONOLAURATE 176.170
177.1200
977055-26-7 POLYETHYLENE GLYCOL (400) MONOOLEATE 176.170
176.200
177.1200
977055-27-8 POLYETHYLENE GLYCOL (600) MONOOLEATE 176.1200
176.170
977168-63-0 POLYETHYLENE GLYCOL (3000) MONOSTEARATE 176.170
977055-40-5 POLYETHYLENE GLYCOL (600) MONOSTEARATE 176.170
177.1200
977162-30-3 POLYETHYLENE GLYCOL-POLYPROPYLENE GLYCOL, MONOBUTYL ETHER, MW 2400-3500 178.1010
977099-57-2 POLYETHYLENE GLYCOL-POLYPROPYLENE GLYCOL, MONOBUTYL ETHER, MW 3300 178.1010
25034-96-2 POLY(ETHYLENE GLYCOL SEBACATE) 175.105
175.300
177.1390
177.2420
25610-84-8 POLYETHYLENEIMINE-EPICHLOROHYDRIN RESINS 175.105
82339-03-5 POLY(ETHYLENE OXIDE-CO-FORMALDEHYDE-CO-4-NONYLPHENOL) PHOSPHATE 178.3570
106392-12-5 POLY(ETHYLENE OXIDE-CO-PROPYLENE OXIDE), BLOCK 176.170
178.3400
24969-25-3 POLY(ETHYLENE OXIDE-CO-TRIOXANE) 177.2470
68441-17-8 POLYETHYLENE, OXIDIZED 172.260
175.105
175.125
176.170
176.180
176.200
176.210
177.1200
177.1620
177.2800
25610-19-9 POLYETHYLENE PHTHALATE 175.105
175.300
177.1390
177.2420
68131-73-7 POLYETHYLENEPOLYAMINE 175.300
977103-74-4 POLYETHYLENE RESINS, CARBOXYL MODIFIED 175.105
177.1600
25038-59-9 POLY(ETHYLENE TEREPHTHALATE) 175.105
175.300
175.320
177.1390
177.1630
177.1850
177.2260
177.2420
177.2800
178.1005
179.45
26877-81-6 POLY(FUMARIC ACID-CO-ETHYLENE) 175.105
176.180
177.1520
70142-34-6 POLY(12-HYDROXYSTEARIC ACID-CO-PEG) 176.170
9004-95-9 POLYOXYETHYLATED (MIN. 3 MOLS) CETYL ALCOHOL 176.200
977028-99-1 POLYOXYETHYLENE (600) DIOLEATE 173.340
176.200
977055-04-1 POLYOXYETHYLENE GLYCOL (400) DILAURATE 178.3520
9016-45-9 POLY(OXYETHYLENE) MONO(NONYLPHENYL) ETHER 177.1632
9004-99-3 POLYOXYETHYLENE 40 MONOSTEARATE 173.340
175.105
977007-42-3 POLYOXYETHYLENE (MW 1540) 176.210
112-60-7 POLYOXYETHYLENE(MW 200) 176.210
2615-15-8 POLYOXYETHYLENE (MW 300) 176.210
977053-61-4 POLYOXYETHYLENE (MW 600) 176.210
977096-97-1 POLYOXYETHYLENE (MW 200) DIBENZOATE 175.105
57171-56-9 POLY(OXYETHYLENE) SORBITOL HEXAOLEATE 177.1632
9005-65-6 POLYSORBATE 80 172.515
172.836
172.838
172.840
172.842
173.340
175.105
176.180
178.3400
73.1
73.1001
68937-55-3 SILOXANES AND SILICONES, DIMETHYL, METHYL HYDROGEN, REACTION PRODUCTS WITH POLYETHYLENE-POLYPROPYLENE GLYCOL MONOALLYL ETHER 176.210
31631-25-1 SODIUM NONOXYNOL SULFATE 178.3400
9002-97-5 SODIUM VINYL SULFONATE POLYMER 176.170
39354-45-5 SULFOSUCCINIC ACID 4-ESTER WITH POLYETHYLENE GLYCOL DODECYL ETHER,DISODIUM SALT 175.105
178.3400
61791-00-2 TALL OIL FATTY ACIDS, PEG ESTERS 175.300
176.180
176.210
177.2800
61791-01-3 TALL OIL FATTY ACIDS, POLYOXYETHYLENE DIESTERS 176.210
177.2800
9004-83-5 TERT-DODECYL THIOETHER OF POLYETHYLENE GLYCOL 176.180
9002-93-1 ALPHA-(P-(1,1,3,3-TETRAMETHYLBUTYL)PHENYL)-OMEGA-HYDROXYPOLY(OXYETHYLENE)(GREATER THAN 1 MOL) 172.710
176.180
176.210
177.1680

* Definitions

  • CAS Reg. No. (or other ID): Chemical Abstract Service (CAS) Registry Number® for the substance or a numerical code (other ID) assigned by CFSAN to those substances that do not have a CAS Registry Number (977nnn-nn-n series).
  • Substance: The name of the additive as recognized by CFSAN.
  • 21 CFR: The Code of Federal Regulations, Title 21 is the preferred reference to determine the regulatory status of Indirect Food Additives. Substances whose names appear in 21 CFR, parts 175-178 are authorized for specified intended users and conditions of use as stated in the regulation. Note that substances may appear in more than one regulation, or several times in the same regulation.

Note that if a substance is mentioned in 21 CFR parts 175-178 and thus, is listed above, any other citations for the same substance in other sections of 21 CFR dealing with food additives (parts 1-199 inclusive) may also be cited.

CAS Reg. No.*
(or other ID)
Substance*
(sorted A-Z)
21 CFR*

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