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U.S. Department of Health and Human Services

GRAS Notices

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GRN No. 989

Bacillus subtilis expressing a modified gene encoding a variant of the wild-type subtilisin from B. clausii

Intended Use: Intended for use as an enzyme to hydrolyze proteins from microbial, plant, milk, and seafood sources at up to 569 mg Total Organic Solids (TOS)/kg raw material.
Basis: Scientific procedures
Notifier: Danisco US Inc. (operating as DuPont Nutrition and Biosciences)
Notifier Address: 925 Page Mill Road
Palo Alto, CA 94304
GRAS Notice (releasable information): GRN 989 with amendments (in PDF) (6.6 MB)
Date of closure: Jun 30, 2022
FDA's Letter: FDA has no questions (in PDF) (144 kB)
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