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U.S. Department of Health and Human Services

FDA Poisonous Plant Database

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AUTHOR(S): Kim, H. L.; Ray, A. C.
TITLE: The effects of hepatic microsomal enzyme inducers and inhibitors on the toxicity of lobeline.
YEAR: 1985 CITATION: Toxicologist, 5(1), 113 [English]
FDA #: F09822
ABSTRACT: Abstract: Lobelia berlandierri is a toxic plant and a basic extract prepared from the dried plant causes electrocardiographic changes and lowers blood pressure in the canine. This crude extract contains several piperidine alkaloids and is also toxic to rodents. Due to the paucity of isolated compounds, a structurally related alkaloid isolated from Lobelia inflata, lobeline, was used as a model. Pretreatment of mice with hepatic microsomal enzyme inducers lowered while an inhibitor enhanced the toxicity of lobeline. The intraperitoneal Ld50 of lobeline sulfate following SKF 524-A (75 mg/kg), phenobarbital (PB), and 3-methylcholanthrene (3-MC) were 18.3, 85.5, and 82.1 mg/kg, respectively, as compared to that of saline treated controls, 55.3 mg/kg. Pretreatment of mice with another hepatic microsomal enzyme inhibitor, hepatic glutathine inducer or depleter exhibited no significant effect on the toxicity of lobeline. These results will be compared with the toxicity of L. berlandierri extract.
GRIN #: 22466 Exit Disclaimer
COMMON NAME
STANDARD COMMON NAME: lobelia
FAMILYCampanulaceae
LATIN NAMELobelia inflata
STANDARD PLANT NAMELobelia inflata L.
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