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U.S. Department of Health and Human Services

FDA Poisonous Plant Database

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AUTHOR(S): Callaway, J. C.; Airaksinen, M. M.; McKenna, D. J.; Brito, G. S.; Grob, C. S.
TITLE: Platelet serotonin uptake sites increased in drinkers of ayahuasca.
YEAR: 1994 CITATION: Psychopharmacology (Berl), 116(3), 385-387 [English]
FDA #: F22746
ABSTRACT: The binding of [3H]citalopram to the platelet 5-hydroxytryptamine (5-HT) transporter was measured in a group of healthy male drinkers of ayahuasca, a psychoactive sacrament indigenous to Amazonia, and a group healthy male controls. An increased number of binding sites (Bmax) in the platelets of ayahuasca drinkers was found, while the dissociation constant (Kd) remained the same for both groups. If indicative of neuronal 5-HT uptake activity, these results would suggest a decreased concentration of extracellular 5-HT, or a response to increased production and release of 5-HT. Such changes in 5-HT synaptic activity, in this case, should not be misinterpreted as an indication of developing neurological or psychiatric illness.
GRIN #: 400033 Exit Disclaimer
COMMON NAME: ayahuasca
LATIN NAMEBansteriopsis caapi
STANDARD PLANT NAMEBanisteriopsis caapi (Spruce ex Griseb.) C. V. Morton