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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 955 Show All Page 1 of 20
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
955 Bacillus subtilis strain BS-MB40 PTA-122264 spore preparation Pending
954 Fibrillated cellulose Pending
953 Lactobacillus plantarum strain CECT 7527, CECT 7528, and CECT 7529 Pending
952 Bifidobacterium animalis subsp. lactis strain AD011 Pending
951 3-fucosyllactose Pending
950 Bifidobacterium longum subsp. infantis DSM 33361 Pending
949 Bacillus coagulans strain DSM 17654 Pending
948 Enzyme-treated pea protein Pending
947 Cacao pulp, juice, and juice concentrate Pending
946 Lactobacillus plantarum strain DSM 33452 Pending
945 Fungal protein from Fusarium sp. mycelia Pending
944 Rice protein hydrolysate Pending
943 Citrus fiber from the peels of oranges, lemons, or limes Pending
942 Whey permeate Dec 21, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (189 kB)
941 Oat polar lipid extract Pending
940 Phospholipase A2 enzyme from Sus scrofa (wild pig) produced by Yarrowia lipolytica Pending
939 Sunflower lecithin Pending
938 Pichia kluyveri DSM 33235 Pending
937 Staphylococcus carnosus DSM 25010 Pending
936 Leuconostoc carnosum DSM 32756 Pending
935 L-carnitine-L-tartrate Pending
934 Algal oil (≥35% docosahexanoic acid (DHA)) derived from Schizochytrium sp. strain CABIO-A-2 Pending
933 Algal oil (≥36% docosahexaenoic acid) from Schizochytrium sp. strain DHF Nov 13, 2020 FDA has no questions (in PDF) (757 kB)
932 2'-fucosyllactose Pending
931 Creatine monohydrate Nov 12, 2020 FDA has no questions (in PDF) (437 kB)
930 Silk fibroin derived from Bombyx mori cocoons Pending
929 2'-fucosyllactose Pending
928 Dried Saccharomyces cerevisiae yeast fermentate Pending
927 Polyvinyl alcohol Pending
926 Soluble rice flour Pending
925 3-fucosyllactose Pending
924 2'-fucosyllactose Nov 23, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF)
923 Lacto-N-tetraose Pending
922 6'-sialyllactose sodium salt Pending
921 3'-sialyllactose sodium salt Oct 30, 2020 FDA has no questions (in PDF) (771 kB)
920 Thaumatin II Pending
919 Lacto-N-neotetraose Oct 30, 2020 FDA has no questions (in PDF) (353 kB)
918 Partially defatted almond protein flour Pending
917 Preparation containing three bacterial phages specific to Salmonella Sep 10, 2020 FDA has no questions (in PDF) (540 kB)
916 Dihydroquercetin Pending
915 Calcium L-methylfolate Pending
914 Alpha-linolenic acid diacylglycerol Pending
913 Algal oil (minimum 35% DHA) Nov 10, 2020 FDA has no questions (in PDF) (906 kB)
912 Trehalose Pending
911 Rebaudioside I Pending
910 Thaumatin II Sep 9, 2020 FDA has no questions (in PDF) (541 kB)
909 Whey protein containing 41% alpha-lactalbumin Pending
908 Lipase from Penicillium camemberti Pending
907 Wheat seed oil Aug 21, 2020 FDA has no questions (in PDF) (593 kB)
906 Wheat seed polar lipids Aug 24, 2020 FDA has no questions (in PDF) (573 kB)

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GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

2362  

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