• Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

GRAS Notices

  • Print
  • Share
  • E-mail
-

The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


Search and display hints:

  • Select the specific GRN number below to view additional details about any GRAS Notice.
  • To sort by a specific field, click on the column header for that field.
  • To browse the records, use the Show All, First/Previous/Next/Last, and Jump To options at the bottom of the data table.
  • To search for a specific substance/term, enter the term in the Search box and select Show Items to display only those records that contain the selected term. (The search results also includes terms not shown on this page, but included in the full record on the detail page.)
  • The search results will return hits of records containing words that include the search term. For example, a search for the color red will return results that include terms such as reduce, ingredient, and cultured. To limit results to only the searched term, place a space before and after the word in the basic search or in the advanced search “this exact phrase” field.
Download GRAS Notices data in Microsoft Excel web format Download data from this searchable database in Excel format. If you need help accessing information in different file formats, see Instructions for Downloading Viewers and Players.
Search within these results
Records Found: 987 Show All Page 1 of 20
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
987 2'-fucosyllactose Pending
986 Chlorella sorokiniana powder and C. sorokiniana micro powder Pending
985 Bifidobacterium longum subsp. infantis strain ATCC SD 6720 Pending
984 Wolffia globosa Pending
983 Purified steviol glycosides from the leaves of Stevia rebaudiana (Bertoni) Pending
982 Polygalacturonase enzyme preparation produced by Aspergillus oryzae expressing a polygalacturonase gene from A. tubingensis Mosseray Pending
981 Sterol esterase enzyme preparation produced by Trichoderma reesei expressing a gene encoding sterol esterase from Melanocarpus albomyces Pending
980 Dry whole milk Jul 13, 2021 FDA has no questions (in PDF) (124 kB)
979 Pectin esterase enzyme preparation produced by Aspergillus oryzae expressing a pectin esterase gene from A. tubingensis Pending
978 Hydrolyzed aqueous olive pulp extract Pending
977 D-tagatose produced via novel enzymatic cascade Pending
976 Sodium hyaluronate Pending
975 Maltogenic alpha-amylase enzyme preparation produced by Bacillus licheniformis carrying the gene coding for maltogenic alpha-amylase from Geobacillus stearothermophilus Pending
974 Maltogenic alpha-amylase enzyme preparation produced by Bacillus subtilis Pending
973 Maple wood fiber Pending
972 Pectin hydrolysate from carrot pomace Pending
971 Bacillus clausii strain 088AE spore preparation Pending
970 Enzyme-modified steviol glycosides Pending
969 Bacillus subtilis “Bss-19” spore preparation Pending
968 Rebaudioside B Pending
967 Soluble egg-white protein produced by Pichia pastoris strain “DFB-003” Pending
966 Preparations containing three to eight bacteriophages specific to Campylobacter jejuni Pending
965 Arabinase enzyme preparation produced by Aspergillus tubingensis Pending
964 Lysophospholipase enzyme preparation from Aspergillus niger produced by Trichoderma reesei Pending
963 Fungal oil (≥40% arachidonic acid) from Mortierella alpina Pending
962 Rice bran wax Pending
961 β-glucan derived from Agrobacterium sp. CCTCC No. M2010020 May 19, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (229 kB)
960 Hypromellose acetate succinate Pending
959 Iron milk proteinate Mar 17, 2021 FDA has no questions (in PDF) (208 kB)
958 Fungal oil (≥40% arachidonic acid) from Mortierella alpina strain AF Mar 26, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (94 kB)
957 Lactobacillus johnsonii strain ATCC PTA-124205 Pending
956 Bacillus subtilis ATCC SD-7280 Pending
955 Bacillus subtilis strain BS-MB40 PTA-122264 spore preparation Mar 26, 2021 FDA has no questions (in PDF) (243 kB)
954 Fibrillated cellulose Pending
953 Lactobacillus plantarum strain CECT 7527, CECT 7528, and CECT 7529 Feb 5, 2021 FDA has no questions (in PDF)
952 Bifidobacterium animalis subsp. lactis strain AD011 Mar 17, 2021 FDA has no questions (in PDF) (160 kB)
951 3-fucosyllactose Pending
950 Bifidobacterium longum subsp. infantis DSM 33361 Mar 1, 2021 FDA has no questions (in PDF) (281 kB)
949 Bacillus coagulans strain DSM 17654 spore preparation Jan 7, 2021 FDA has no questions (in PDF)
948 Enzyme-treated pea protein Pending
947 Cacao pulp, juice, and juice concentrate Pending
946 Lactobacillus plantarum strain DSM 33452 Feb 5, 2021 FDA has no questions (in PDF) (91 kB)
945 Fungal protein from Fusarium sp. mycelia Pending
944 Rice protein hydrolysate Pending
943 Citrus fiber from the peels of oranges, lemons, or limes Pending
942 Whey permeate Dec 21, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (189 kB)
941 Oat polar lipid extract Pending
940 Phospholipase A2 enzyme from Sus scrofa (wild pig) produced by Yarrowia lipolytica Pending
939 Sunflower lecithin FDA has no questions (in PDF) (109 kB)
938 Pichia kluyveri DSM 33235 Pending

Show All 

jump to page of 20 


GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

2362  

-
-