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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 968 Show All Page 1 of 20
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
968 Rebaudioside B Pending
967 Soluble egg-white protein produced by Pichia pastoris strain “DFB-003” Pending
966 Preparations containing three to eight bacteriophages specific to Campylobacter jejuni Pending
965 Arabinase enzyme preparation produced by Aspergillus tubingensis Pending
964 Lysophospholipase enzyme preparation from Aspergillus niger produced by Trichoderma reesei Pending
963 Fungal oil (≥40% arachidonic acid) from Mortierella alpina Pending
962 Rice bran wax Pending
961 β-glucan derived from Agrobacterium sp. CCTCC No. M2010020 Pending
960 Hypromellose acetate succinate Pending
959 Iron milk proteinate Mar 17, 2021 FDA has no questions (in PDF) (208 kB)
958 Fungal oil (≥40% arachidonic acid) from Mortierella alpina strain AF Mar 26, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (94 kB)
957 Lactobacillus johnsonii strain ATCC PTA-124205 Pending
956 Bacillus subtilis ATCC SD-7280 Pending
955 Bacillus subtilis strain BS-MB40 PTA-122264 spore preparation Mar 26, 2021 FDA has no questions (in PDF) (243 kB)
954 Fibrillated cellulose Pending
953 Lactobacillus plantarum strain CECT 7527, CECT 7528, and CECT 7529 Feb 5, 2021 FDA has no questions (in PDF)
952 Bifidobacterium animalis subsp. lactis strain AD011 Mar 17, 2021 FDA has no questions (in PDF) (160 kB)
951 3-fucosyllactose Pending
950 Bifidobacterium longum subsp. infantis DSM 33361 Pending
949 Bacillus coagulans strain DSM 17654 spore preparation Jan 7, 2021 FDA has no questions (in PDF)
948 Enzyme-treated pea protein Pending
947 Cacao pulp, juice, and juice concentrate Pending
946 Lactobacillus plantarum strain DSM 33452 Feb 5, 2021 FDA has no questions (in PDF) (91 kB)
945 Fungal protein from Fusarium sp. mycelia Pending
944 Rice protein hydrolysate Pending
943 Citrus fiber from the peels of oranges, lemons, or limes Pending
942 Whey permeate Dec 21, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (189 kB)
941 Oat polar lipid extract Pending
940 Phospholipase A2 enzyme from Sus scrofa (wild pig) produced by Yarrowia lipolytica Pending
939 Sunflower lecithin FDA has no questions (in PDF) (109 kB)
938 Pichia kluyveri DSM 33235 Pending
937 Staphylococcus carnosus DSM 25010 Apr 21, 2021 FDA has no questions (in PDF) (195 kB)
936 Leuconostoc carnosum DSM 32756 Pending
935 L-carnitine-L-tartrate Nov 30, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (242 kB)
934 Algal oil (≥35% docosahexanoic acid (DHA)) derived from Schizochytrium sp. strain CABIO-A-2 Pending
933 Algal oil (≥36% docosahexaenoic acid) from Schizochytrium sp. strain DHF Nov 13, 2020 FDA has no questions (in PDF) (757 kB)
932 2'-fucosyllactose Pending
931 Creatine monohydrate Nov 12, 2020 FDA has no questions (in PDF) (437 kB)
930 Silk fibroin derived from Bombyx mori cocoons Pending
929 2'-fucosyllactose Pending
928 Dried Saccharomyces cerevisiae yeast fermentate Pending
927 Polyvinyl alcohol Pending
926 Soluble rice flour Jan 5, 2021 FDA has no questions (in PDF) (434 kB)
925 3-fucosyllactose Feb 8, 2021 FDA has no questions (in PDF) (190 kB)
924 2'-fucosyllactose Nov 23, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF)
923 Lacto-N-tetraose Feb 2, 2021 FDA has no questions (in PDF) (187 kB)
922 6'-sialyllactose sodium salt Pending
921 3'-sialyllactose sodium salt Oct 30, 2020 FDA has no questions (in PDF) (771 kB)
920 Thaumatin II Pending
919 Lacto-N-neotetraose Oct 30, 2020 FDA has no questions (in PDF) (353 kB)

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GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

2362  

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