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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

The inventory notes what type of response letter the FDA sent in response to the notice. Notifiers often resubmit notices that FDA previously ceased to evaluate at the notifier’s request, and resubmitted notices commonly receive a letter indicating FDA has no questions, after addressing deficiencies. In the inventory, entries for notices that were later resubmitted link to the newer entry in the final column. Newer entries for notices that were resubmitted include a link to the previous submission below the substance name.

Some GRNs that FDA previously ceased to evaluate at the notifier’s request were later resubmitted as a food additive petition. For each of these cases, the GRN detail page links to the food additive petition.

After issuing a response letter, we may issue a subsequent letter as circumstances warrant. The issue dates of any subsequent letters are listed under the column, "Date of add’l correspondence.”

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


Search and display hints:

  • Select the specific GRN number below to view additional details about any GRAS Notice.
  • To sort by a specific field, click on the column header for that field.
  • To browse the records, use the Show All, First/Previous/Next/Last, and Jump To options at the bottom of the data table.
  • To search for a specific substance/term, enter the term in the Search box and select Show Items to display only those records that contain the selected term. (The search results also includes terms not shown on this page, but included in the full record on the detail page.)
  • The search results will return hits of records containing words that include the search term. For example, a search for the color red will return results that include terms such as reduce, ingredient, and cultured. To limit results to only the searched term, place a space before and after the word in the basic search or in the advanced search “this exact phrase” field.
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Records Found: 1181 Show All Page 1 of 24
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
  1181
Weizmannia coagulans LMG S-31876 spore preparation Pending
  1180
Cellobiose Pending
  1179
Liquid whole cow milk Pending
  1178
Rebaudioside I obtained by enzymatic treatment of steviol glycosides purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside I) Pending
  1177
Bacillus coagulans “Unique IS-2” spore preparation Pending
  1176
Lacto-N-tetraose Pending
  1175
Lactiplantibacillus plantarum DSM 23881 Pending
  1174
Dry whole goat milk Pending
  1173
Invertase enzyme preparation produced by Trichoderma reesei expressing a gene for invertase from Aspergillus niger Pending
  1172
Liquid milk, either whole or nonfat, combined with lactose and water Pending
  1171
Non-animal type 21 collagen polypeptide Pending
  1170
Resistant dextrin from tapioca in powder or syrup form Pending
  1169
6′-sialyllactose sodium salt Pending
  1168
Tigernuts flour Pending
  1167
Brazzein produced by Komagataella phaffii expressing a gene encoding for brazzein from Pentadiplandra brazzeana Pending
  1166
Fava bean (Vicia faba L.) protein hydrolysate Pending
  1165
(R)-1,3-butanediol Pending
  1164
A chemically synthesized analog of pediocin PA-1 specific to Listeria monocytogenes Pending
  1163
A preparation containing two bacteriophages (phage) specific to Salmonella enterica Pending
  1162
Fungal oil (≥38% arachidonic acid (ARA)) from Mortierella alpina FJRK-MA01 Feb 8, 2024 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (236 kB)
  1161
Triacylglycerol lipase enzyme preparation produced by Candida cylindracea Pending
  1160
Lemna leaf protein Pending
  1159
Bacillus coagulans strain BCP92 spore preparation Pending
  1158
Lactiplantibacillus plantarum DSM 34613 Pending
  1157
2'-fucosyllactose Pending
  1156
Algal oil (≥35% docosahexaenoic acid) from Schizochytrium sp. FJRK-SCH3 Feb 8, 2024 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (204 kB)
  1155
1-methylcyclopropene Apr 23, 2024 FDA has no questions (in PDF) (208 kB)
  1154
Triacylglycerol lipase enzyme preparation produced by Komagataella phaffii expressing the gene encoding lipase from Fusarium oxysporum Pending
  1153
Pongamia bean oil Pending
  1152
Phoenix oyster mushroom (Pleurotus pulmonarius) mycelia biomass Pending
  1151
Fava bean protein Pending
  1150
Triacylglycerol lipase enzyme preparation produced by Trichoderma reesei expressing a gene for triacylglycerol lipase from Thermomyces lanuginosis Pending
  1149
High-selenium Saccharomyces cerevisiae yeast Dec 12, 2023 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (98 kB)
  1148
D-psicose Pending
  1147
Copper(II) ion Pending
  1146
Nuclease enzyme preparation produced by Bacillus amyloliquefaciens expressing the gene encoding a nuclease from Serratia marcescens Pending
  1145
β-lactoglobulin produced by Aspergillus oryzae strain Ao_st0002 Pending
  1144
Miracle fruit (Synsepalum dulcificum) powder Pending
  1143
Bacillus subtilis NRRL 68053 Pending
  1142
Brazzein produced by Komagataella phaffii expressing a gene encoding for brazzein from Pentadiplandra brazzeana Mar 11, 2024 FDA has no questions (in PDF) (257 kB)
  1141
L-α-glycerophosphorylcholine Pending
  1140
Enzyme-modified steviol glycosides Pending
  1139
Transglutaminase enzyme preparation produced by Bacillus licheniformis carrying a gene encoding transglutaminase from Streptomyces mobaraensis Pending
  1138
Hydroxytyrosol Pending
  1137
Protein-sucrose Jan 19, 2024 FDA has no questions (in PDF) (188 kB)
  1136
Dry whole goat milk Oct 31, 2023 FDA has no questions (in PDF) (267 kB)
  1135
Galacto-oligosaccharides Nov 3, 2023 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (133 kB)
  1134
Bacteriophage preparation specific to Salmonella Enteritidis Feb 8, 2024 FDA has no questions (in PDF) (180 kB)
  1133
Resistant dextrin from corn Pending
  1132
Hydrolyzed poultry protein Pending

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GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
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