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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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Records Found: 1068 Show All Page 1 of 22
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
1068 Lacto-N-tetraose Pending
1067 Lacto-N-neotetraose Pending
1066 Carnobacterium divergens strain M35 Pending
1065 Anaerobutyricum soehngenii CH106 Pending
1064 Pomegranate extract Pending
1063 Weissella cibaria CMU Pending
1062 Saccharomyces cerevisiae strain OYR-185 Pending
1061 Deactivated alkaline serine protease produced by Bacillus licheniformis strain CICC 10266 Pending
1060 2'-fucosyllactose Pending
1059 Lacto-N-neotetraose Pending
1058 Polyvinyl alcohol Pending
1057 D-psicose Pending
1056 β-lactoglobulin produced by Komagataella phaffii strain “yRMK-66” Pending
1055 Xylanase enzyme preparation produced by Bacillus licheniformis strain expressing the xylanase gene from Chryseobacterium Pending
1054 Glucose oxidase enzyme preparation produced by Aspergillus niger expressing the gene encoding glucose oxidase from A. niger Pending
1053 6'-sialyllactose sodium salt Pending
1052 3'-sialyllactose sodium salt Pending
1051 2'-fucosyllactose Pending
1050 High 2-palmitic acid vegetable oil Jul 18, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (175 kB)
1049 Medium-chain triacylglycerols Pending
1048 Aminopeptidase enzyme preparation produced by Trichoderma reesei expressing a gene encoding an aminopeptidase from Aspergillus clavatus Pending
1047 Lipase enzyme preparation produced by Saccharomyces cerevisiae expressing a gene encoding a lipase from Fusarium oxysporum Pending
1046 Collagenase enzyme preparation from genetically modified Streptomyces violaceoruber expressing a collagenase gene Pending
1045 Resistant dextrin from tapioca Pending
1044 Calcium disodium ethylenediaminetetraacetic acid May 25, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (118 kB)
1043 Cetylated fatty acids Pending
1042 Menaquinone-7 derived from a specific strain of Bacillus subtilis natto Pending
1041 Dry whole milk May 10, 2022 FDA has no questions (in PDF) (2.0 MB)
1040 2'-fucosyllactose Pending
1039 Lactase enzyme preparation produced by Aspergillus oryzae Pending
1038 Preparation containing six bacteriophages (phage) specific to Salmonella enterica spp. serovars Pending
1037 3-fucosyllactose Pending
1036 Complexation products of iron with sodium citrate Pending
1035 Lacto-N-fucopentaose I with 2′-fucosyllactose Pending
1034 2'-fucosyllactose Pending
1033 Hydrolyzed Saccharomyces cerevisiae Pending
1032 D-β-hydroxybutyrate Jun 2, 2022 FDA has no questions (in PDF) (214 kB)
1031 Barley and rice protein hydrolysate Pending
1030 Cellulase enzyme preparation produced by Aspergillus niger genetically engineered to express a cellulase gene from Trichoderma reesei Pending
1029 D-psicose Pending
1028 Metschnikowia pulcherrima DANMET-A and M. fructicola DANMET-B Pending
1027 Miracle fruit (Synsepalum dulcificum) powder Dec 22, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (137 kB)
1026 Silk fibroin derived from Bombyx mori cocoons Pending
1025 Pepsin A enzyme preparation produced by Pichia pastoris to overexpress the gene encoding pepsin A Pending
1024 D-psicose Pending
1023 Monosodium L-5-methyltetrahydrofolate Jan 25, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (85 kB)
1022 Streptococcus salivarius DB-B5 Pending
1021 Transglutaminase enzyme preparation produced by Streptomyces mobaraensis strain M2020197 Pending
1020 Protein from Helianthus annuus (sunflower protein) Jun 14, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (101 kB)
1019 Agave mixed fructans from Agave tequilana Weber var. azul Pending

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GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

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