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U.S. Department of Health and Human Services

Final Rules: Food Additives and Color Additives
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Petition(s): GRP 5G0049

Nisin Preparation; Affirmation of GRAS Status as a Direct Human Food Ingredient

Petitioner: Aplin and Barrett Ltd.
Docket number (legacy and/or former docket number(s)): (75G-0265)
Subject additive and intended use: affirming that nisin preparation produced from Streptococcus lactis Lancefield Group N is generally recognized as safe (GRAS) for use as an optional antimicrobial agent to inhibit the outgrowth of Clostridium botulinum spores and toxin formation in certain pasteurized cheese spreads
21 CFR* affected: 184.1538 Nisin preparation
Substance(s)*, (CAS Registry® No.): nisin, (1414-45-5)
Federal Register publication history: Sep 17, 1975 40 FR 42912 Notice
Apr 6, 1988 53 FR 11247 Final Rule Apr 6, 1988

 

*Definitions

  • 21 CFR: Title 21 of the Code of Federal Regulations.
  • Substance: The name of the substance listed in the CFR.
  • CAS Registry® No.: Chemical Abstract Service (CAS) Registry Number® for the substance.
  • Petitions (see also Questions and Answers About the Petition Process)
    • FAP: Food Additive Petition
    • CAP: Color Additive Petition
    • GRP: GRAS Affirmation Petition (replaced by GRAS Notification Program in 1998)
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