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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

The inventory notes what type of response letter the FDA sent in response to the notice. Notifiers often resubmit notices that FDA previously ceased to evaluate at the notifier’s request, and resubmitted notices commonly receive a letter indicating FDA has no questions, after addressing deficiencies. In the inventory, entries for notices that were later resubmitted link to the newer entry in the final column. Newer entries for notices that were resubmitted include a link to the previous submission below the substance name.

Some GRNs that FDA previously ceased to evaluate at the notifier’s request were later resubmitted as a food additive petition. For each of these cases, the GRN detail page links to the food additive petition.

After issuing a response letter, we may issue a subsequent letter as circumstances warrant. The issue dates of any subsequent letters are listed under the column, "Date of add’l correspondence.”

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


Search and display hints:

  • Select the specific GRN number below to view additional details about any GRAS Notice.
  • To sort by a specific field, click on the column header for that field.
  • To browse the records, use the Show All, First/Previous/Next/Last, and Jump To options at the bottom of the data table.
  • To search for a specific substance/term, enter the term in the Search box and select Show Items to display only those records that contain the selected term. (The search results also includes terms not shown on this page, but included in the full record on the detail page.)
  • The search results will return hits of records containing words that include the search term. For example, a search for the color red will return results that include terms such as reduce, ingredient, and cultured. To limit results to only the searched term, place a space before and after the word in the basic search or in the advanced search “this exact phrase” field.
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Records Found: 1181 Show All Page 1 of 24
GRN No. Substance Date of closure
(sorted Z-A)
FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
  1142
Brazzein produced by Komagataella phaffii expressing a gene encoding for brazzein from Pentadiplandra brazzeana Mar 11, 2024 FDA has no questions (in PDF) (257 kB)
  1156
Algal oil (≥35% docosahexaenoic acid) from Schizochytrium sp. FJRK-SCH3 Feb 8, 2024 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (204 kB)
  1162
Fungal oil (≥38% arachidonic acid (ARA)) from Mortierella alpina FJRK-MA01 Feb 8, 2024 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (236 kB)
  1134
Bacteriophage preparation specific to Salmonella Enteritidis Feb 8, 2024 FDA has no questions (in PDF) (180 kB)
  1127
Lactiplantibacillus plantarum ATCC-202195 Feb 1, 2024 FDA has no questions (in PDF) (235 kB)
  1057
D-psicose Jan 25, 2024 FDA has no questions (in PDF) (298 kB)
  1137
Protein-sucrose Jan 19, 2024 FDA has no questions (in PDF) (188 kB)
  1149
High-selenium Saccharomyces cerevisiae yeast Dec 12, 2023 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (98 kB)
  1097
Maltogenic alpha-amylase enzyme preparation produced by Escherichia coli expressing a gene encoding a maltogenic alpha-amylase from Geobacillus stearothermophilus Dec 7, 2023 FDA has no questions (in PDF) (247 kB)
  1091
2'-fucosyllactose Dec 1, 2023 FDA has no questions (in PDF) (272 kB)
  1051
2'-fucosyllactose Nov 21, 2023 FDA has no questions (in PDF) (298 kB)
  1107
Bifidobacterium longum subsp. infantis strain LMG 11588 Nov 15, 2023 FDA has no questions (in PDF) (241 kB)
  1123
Sucrose fatty acid esters Nov 3, 2023 FDA has no questions (in PDF) (214 kB)
  1135
Galacto-oligosaccharides Nov 3, 2023 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (133 kB)
  1136
Dry whole goat milk Oct 31, 2023 FDA has no questions (in PDF) (267 kB)
  1084
Lactobacillus rhamnosus KCTC 12202BP Oct 31, 2023 FDA has no questions (in PDF) (247 kB)
  1079
Bifidobacterium longum strain KCTC 12200BP Oct 31, 2023 FDA has no questions (in PDF) (240 kB)
  1083
Lactobacillus acidophilus KCTC 11906BP Oct 31, 2023 FDA has no questions (in PDF) (218 kB)
  1082
Bifidobacterium lactis strain KCTC 11904BP Oct 31, 2023 FDA has no questions (267 kB)
  1085
Lactobacillus casei strain KCTC 12398BP Oct 27, 2023 FDA has no questions (in PDF) (313 kB)
  1086
Lactobacillus plantarum KCTC 10782BP Oct 27, 2023 FDA has no questions (in PDF) (291 kB)
  1100
Fractionated whey protein concentrate containing 41% alpha-lactalbumin Oct 27, 2023 FDA has no questions (259 kB)
  1131
Bacillus subtilis ATCC BS50 PTA-127287 Oct 20, 2023 FDA has no questions (in PDF) (267 kB)
  1104
Egg-white protein produced by Komagataella phaffii ATCC GSD-1235 Oct 17, 2023 FDA has no questions (in PDF) (264 kB)
  1124
β-glucans from Hericium erinaceus strain BCRC 35669 Sep 28, 2023 At the notifier's request, FDA Ceased to evaluate this notice (in PDF) (209 kB)
  1130
Lactobacillus rhamnosus CGMCC21225 Sep 28, 2023 FDA has no questions (in PDF) (248 kB)
  1115
Fungal oil (≥40% arachidonic acid (ARA)) from Mortierella alpina strain AF Sep 18, 2023 FDA has no questions (in PDF) (256 kB)
  1095
Bacillus subtilis strain ATCC AAN000002 spore preparation Sep 11, 2023 FDA has no questions (in PDF) (286 kB)
  1101
Dried biomass of Chlamydomonas reinhardtii strain TAI114 Sep 1, 2023 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (161 kB)
  1099
3-fucosyllactose Aug 29, 2023 FDA has no questions (in PDF) (292 kB)
  1108
Lactiplantibacillus plantarum strain MCC 0537 Aug 16, 2023 FDA has no questions (In PDF) (290 kB)
  1029
D-psicose Aug 4, 2023 FDA has no questions (in PDF) (255 kB)
  1118
Pyrroloquinoline quinone disodium salt Jul 31, 2023 FDA has no questions (in PDF) (353 kB)
  1113
Lactobacillus plantarum NCIMB 30562 Jul 20, 2023 FDA has no questions (in PDF) (419 kB)
  1054
Glucose oxidase enzyme preparation produced by Aspergillus niger expressing the gene encoding glucose oxidase from A. niger Jul 14, 2023 FDA has no questions (in PDF) (270 kB)
  1114
Bifidobacterium breve DSM 33444 Jul 10, 2023 FDA has no questions (in PDF) (141 kB)
  1096
Saccharomyces cerevisiae strain OYR-243 Jul 5, 2023 FDA has no questions (in PDF) (212 kB)
  1092
Bifidobacterium animalis subsp. lactis IDCC 4301 Jun 23, 2023 FDA has no Questions (271 kB)
  1046
Collagenase enzyme preparation from genetically modified Streptomyces violaceoruber expressing a collagenase gene Jun 22, 2023 FDA has no questions (in PDF) (219 kB)
  1089
Lactobacillus gasseri strain NCIMB 30370 Jun 20, 2023 FDA has no questions (in PDF) (244 kB)
  1106
Rebaudioside I obtained by enzymatic treatment of steviol glycosides purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside I) Jun 16, 2023 FDA has no questions (in PDF) (277 kB)
  1105
Polyglycerol polyricinoleic acid Jun 14, 2023 FDA has no questions (in PDF) (225 kB)
  1058
Polyvinyl alcohol Jun 9, 2023 FDA has no questions (in PDF) (283 kB)
  1093
Lacticaseibacillus rhamnosus IDCC 3201 Jun 9, 2023 FDA has no Questions (265 kB)
  1068
Lacto-N-tetraose Jun 5, 2023 FDA has no questions (in PDF) (302 kB)
  1053
6'-sialyllactose sodium salt May 12, 2023 FDA Has No Questions (in PDF) (266 kB)
  1038
Preparation containing six bacteriophages (phage) specific to Salmonella enterica spp. serovars May 11, 2023 FDA has no questions (in PDF) (333 kB)
  1052
3'-sialyllactose sodium salt Apr 18, 2023 FDA has no questions (in PDF) (292 kB)
  1065
Anaerobutyricum soehngenii CH106 Apr 14, 2023 FDA has no questions (in PDF) (222 kB)
  1063
Weissella cibaria CMU Apr 14, 2023 FDA has no questions (in PDF) (254 kB)

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GRN No. Substance Date of closure
(sorted Z-A)
FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
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