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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

The inventory notes what type of response letter the FDA sent in response to the notice. Notifiers often resubmit notices that FDA previously ceased to evaluate at the notifier’s request, and resubmitted notices commonly receive a letter indicating FDA has no questions, after addressing deficiencies. In the inventory, entries for notices that were later resubmitted link to the newer entry in the final column. Newer entries for notices that were resubmitted include a link to the previous submission below the substance name.

Some GRNs that FDA previously ceased to evaluate at the notifier’s request were later resubmitted as a food additive petition. For each of these cases, the GRN detail page links to the food additive petition.

After issuing a response letter, we may issue a subsequent letter as circumstances warrant. The issue dates of any subsequent letters are listed under the column, "Date of add’l correspondence.”

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
  • To sort by a specific field, click on the column header for that field.
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  • To search for a specific substance/term, enter the term in the Search box and select Show Items to display only those records that contain the selected term. (The search results also includes terms not shown on this page, but included in the full record on the detail page.)
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Records Found: 63 Show 50 records at a time
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
  1178
Rebaudioside I obtained by enzymatic treatment of steviol glycosides purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside I) Pending
  1140
Enzyme-modified steviol glycosides Pending
  1106
Rebaudioside I obtained by enzymatic treatment of steviol glycosides purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside I) Jun 16, 2023 FDA has no questions (in PDF) (277 kB)
  1010
Rebaudioside M obtained by enzymatic treatment of steviol glycosides purified from the leaves of Stevia rebaudiana (Bertoni) Jan 26, 2022 FDA has no questions (in PDF) (412 kB)
  999
Enzyme-modified steviol glycosides Dec 3, 2021 FDA has no questions (in PDF) (172 kB)
  983
Purified steviol glycosides from the leaves of Stevia rebaudiana (Bertoni) Jun 28, 2021 FDA has no questions (in PDF) (202 kB)
  970
Enzyme-modified steviol glycosides Apr 9, 2021 FDA has no questions (in PDF) (225 kB)
  878
Glucosylated steviol glycosides Dec 19, 2019 FDA has no questions (in PDF) (453 kB) May 11, 2020
  858
Glucosylated steviol glycosides Oct 4, 2019 FDA has no questions (in PDF) (86 kB)
  839
Purified steviol glycosides Jul 8, 2019 FDA has no questions (in PDF) (77 kB)
  838
Purified steviol glycosides Jul 12, 2019 FDA has no questions (in PDF) (83 kB)
  821
Glucosylated steviol glycosides May 7, 2019 FDA has no questions (in PDF) (743 kB)
  795
Purified steviol glycosides Sep 25, 2018 FDA has no questions (in PDF) (105 kB)
  790
Steviol glycosides (minimum purity 95%) Feb 26, 2019 FDA has no questions (in PDF) (448 kB)
  768
Stevia leaf extract Aug 13, 2018 FDA has no questions (in PDF) (100 kB)
  759
Steviol glycosides consisting primarily of rebaudioside M produced in Yarrowia lipolytica May 25, 2018 FDA has no questions (in PDF) (106 kB)
  745
Steviol glycosides consisting primarily of rebaudioside M Apr 20, 2018 FDA has no questions (in PDF) (103 kB)
  744
Steviol glycosides consisting primarily of rebaudioside M Mar 23, 2018 FDA has no questions (in PDF) (131 kB)
  733
Purified steviol glycosides Jan 9, 2018 FDA has no questions (in PDF) (69 kB)
  702
Purified steviol glycosides Sep 28, 2017 FDA has no questions (in PDF) (65 kB)
  662
Glucosylated steviol glycosides (minimum purity 95%) Sep 29, 2016 FDA has no questions
  656
Enzyme-modified steviol glycosides Sep 28, 2016 FDA has no questions
  638
High purity steviol glycosides (minimum purity 97%) consisting primarily of rebaudioside A Jul 10, 2016 FDA has no questions
  626
Steviol glycosides produced in Saccharomyces cerevisiae May 27, 2016 FDA has no questions
  619
Purified steviol glycosides May 27, 2016 FDA has no questions
  607
Glucosylated steviol glycosides (minimum purity 80%) Oct 14, 2016 FDA has no questions Nov 15, 2019
  555
High purity steviol glycosides (minimum purity 95%) consisting primarily of rebaudioside A. Apr 21, 2015 FDA has no questions
  548
High purity rebaudioside D Apr 22, 2015 FDA has no questions
  536
High purity rebaudioside C Feb 12, 2015 FDA has no questions
  516
Steviol glycosides with rebaudioside A and stevioside as the principal components Oct 31, 2014 FDA has no questions
  512
High purity Rebaudioside M Oct 24, 2014 FDA has no questions
  493
High purity steviol glycosides (minimum purity 95%) May 30, 2014 FDA has no questions
  473
Purified steviol glycosides with rebaudioside X as the principal component Dec 17, 2013 FDA has no questions
  467
Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni Nov 25, 2013 FDA has no questions
  461
Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside A) Aug 14, 2013 FDA has no questions
  456
Rebaudioside D purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside D) Jul 1, 2013 FDA has no questions
  452
Enzyme-modified steviol glycosides Jul 1, 2013 FDA has no questions Dec 10, 2018
  448
Enzyme-modified steviol glycosides May 3, 2013 FDA has no questions
  418
Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside A) Jun 7, 2012 FDA has no questions
  395
Steviol glycosides with rebaudioside A and stevioside as the principal components Jan 24, 2012 FDA has no questions
  393
Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside A) Jan 23, 2012 FDA has no questions
  389
Steviol glycosides with stevioside as the principal component Jan 18, 2012 FDA has no questions
  388
Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside A) Jan 9, 2012 FDA has no questions
  380
Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside A) Nov 28, 2011 FDA has no questions
  375
Enzyme-modified steviol glycosides Sep 2, 2011 FDA has no questions
  369
Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni   Oct 11, 2011 FDA has no questions
  367
Purified steviol glycosides with rebaudioside A and stevioside as the principal components Jul 8, 2011 FDA has no questions Dec 7, 2016
  365
Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside A)   Aug 18, 2011 FDA has no questions
  354
Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside A) Jul 15, 2011 FDA has no questions
  349
Purified steviol glycosides with rebaudioside A and stevioside as the principal components Jul 14, 2011 FDA has no questions
  348
Stevioside purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (stevioside) Jul 14, 2011 FDA has no questions
  337
Enzyme-modified steviol glycosides preparation (EMSGP) Jun 17, 2011 FDA has no questions
  329
Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni Sep 10, 2010 FDA has no questions
  323
Purified steviol glycosides with rebaudioside A and stevioside as the principal components Jul 9, 2010 FDA has no questions Mar 4, 2011
  318
Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni May 15, 2010 FDA has no questions
  304
Purified steviol glycosides with rebaudioside A and stevioside as the principal components Mar 22, 2010 FDA has no questions
  303
Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni Mar 22, 2010 FDA has no questions
  287
Purified steviol glycosides with rebaudioside A and stevioside as the principal components Aug 28, 2009 FDA has no questions
  282
Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni Aug 11, 2009 FDA has no questions
  278
Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni Jul 20, 2009 FDA has no questions
  275
Purified steviol glycosides with rebaudioside A as the principal component Jun 11, 2009 FDA has no questions
  253
Rebaudioside A purified from Stevia rebaudiana (Bertoni) Bertoni Dec 17, 2008 FDA has no questions
  252
Rebaudioside A purified from Stevia rebaudiana (Bertoni) Bertoni Dec 17, 2008 FDA has no questions

GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
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