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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

The inventory notes what type of response letter the FDA sent in response to the notice. Notifiers often resubmit notices that FDA previously ceased to evaluate at the notifier’s request, and resubmitted notices commonly receive a letter indicating FDA has no questions, after addressing deficiencies. In the inventory, entries for notices that were later resubmitted link to the newer entry in the final column. Newer entries for notices that were resubmitted include a link to the previous submission below the substance name.

Some GRNs that FDA previously ceased to evaluate at the notifier’s request were later resubmitted as a food additive petition. For each of these cases, the GRN detail page links to the food additive petition.

After issuing a response letter, we may issue a subsequent letter as circumstances warrant. The issue dates of any subsequent letters are listed under the column, "Date of add’l correspondence.”

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


Search and display hints:

  • Select the specific GRN number below to view additional details about any GRAS Notice.
  • To sort by a specific field, click on the column header for that field.
  • To browse the records, use the Show All, First/Previous/Next/Last, and Jump To options at the bottom of the data table.
  • To search for a specific substance/term, enter the term in the Search box and select Show Items to display only those records that contain the selected term. (The search results also includes terms not shown on this page, but included in the full record on the detail page.)
  • The search results will return hits of records containing words that include the search term. For example, a search for the color red will return results that include terms such as reduce, ingredient, and cultured. To limit results to only the searched term, place a space before and after the word in the basic search or in the advanced search “this exact phrase” field.
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Records Found: 1181 Show All Page 21 of 24
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
  181
Phytosterols Mar 16, 2006 FDA has no questions
  180
Allyl isothiocyanate Mar 16, 2006 FDA has no questions
  179
Polyglycerol polyricinoleic acid Jan 20, 2006 FDA has no questions
  178
Sodium iron EDTA Jan 11, 2006 FDA has no questions
  177
Plant sterol esters Dec 20, 2005 FDA has no questions
  176
Plant sterols and plant sterol esters from vegetable oils or sterols/stanols from tall oil Jan 13, 2006 FDA has no questions
  175
Saccharomyces cerevisiae strain ECMo01 with enhanced expression of urea amidolyase Jan 6, 2006 FDA has no questions
  174
Lysozyme (human) enzyme preparation from rice Sep 13, 2005 At the notifier's request, FDA ceased to evaluate this notice
  173
Lycopene from Blakeslea trispora Dec 1, 2005 FDA has no questions; some uses may require a color additive listing
  172
Isomalto-oligosaccharide Oct 17, 2005 At the notifier's request, FDA ceased to evaluate this notice
  246
  171
Lactobacillus acidophilus, Lactobacillus lactis, and Pediococcus acidilactici Dec 7, 2005 FDA has no questions Sep 13, 2006
  170
Shrimp-derived chitosan Oct 31, 2005 At the notifier's request, FDA ceased to evaluate this notice
  443
  169
Bovine globulin Jul 19, 2005 At the notifier's request, FDA ceased to evaluate this notice
  234
  168
Poultry protein Nov 18, 2005 FDA has no questions
  167
Carbon monoxide Sep 29, 2005 FDA has no questions
  166
Carbon monoxide Sep 29, 2005 At the notifier's request, FDA ceased to evaluate this notice
  165
Quillaia extract type 1 Nov 9, 2005 FDA has no questions
  164
Lauramide arginine ethyl ester Sep 1, 2005 FDA has no questions Jul 25, 2010
  163
Tomato pulp powder Aug 8, 2005 FDA has no questions Sep 15, 2010
Jan 26, 2007
  162
Lactoferrin (human) purified from rice Nov 16, 2006 At the notifier's request, FDA ceased to evaluate this notice
  161
Chlorine dioxide, generated using sodium chlorite in calcined or sulfated kaolin clay Apr 4, 2005 FDA has no questions
  160
Micro-algal oil (Ulkenia sp.) Apr 1, 2005 At the notifier's request, FDA ceased to evaluate this notice
  319
  159
Carnobacterium maltaromaticum strain CB1 May 27, 2005 FDA has no questions
  158
Lipase preparation from Aspergillus niger expressing a gene encoding a lipase from Candida antartica Mar 16, 2005 FDA has no questions
  157
Calcium propionate (alternative method of manufacture) Dec 13, 2004 FDA has no questions
  156
Tomato lycopene extract 6 percent, tomato lycopene extract 1.5 percent, and crystallized tomato lycopene extract Feb 7, 2005 FDA has no questions; some uses may require a color additive listing Sep 15, 2010
  155
alpha-Cyclodextrin Dec 22, 2004 FDA has no questions
  154
Dried orange pulp Dec 13, 2004 FDA has no questions
  153
Conjugated linoleic acid Aug 16, 2004 At the notifier's request, FDA ceased to evaluate this notice
  232
  152
Sodium iron EDTA Dec 9, 2004 FDA has no questions
  151
Ethanol (ethyl alcohol) Oct 29, 2004 FDA has no questions
  150
Glucosamine hydrochloride prepared from chitin obtained from Aspergillus niger Sep 9, 2004 At the notifier's request, FDA ceased to evaluate this notice
  149
Beta-glucanase enzyme preparation from Trichoderma harzianum Sep 27, 2004 FDA has no questions
  148
Vegetable oil conjugated linoleic acid preparation Aug 31, 2004 At the notifier's request, FDA ceased to evaluate this notice
  232
  147
Extracted "seafood species" protein Aug 26, 2004 FDA has no questions Nov 21, 2008
Nov 14, 2008
  146
Salmon oil Aug 17, 2004 FDA has no questions
  145
Phospholipase A2 enzyme preparation from Streptomyces violaceoruber Jul 29, 2004 FDA has no questions
  144
Adenosine 5'-monophosphoric acid and its monosodium and disodium salts Jul 29, 2004 FDA has no questions
  143
Carbon monoxide Jul 29, 2004 FDA has no questions
  142
Phospholipase enzyme preparation from Aspergillus oryzae expressing the gene encoding a phospholipase A1 from Fusarium venenatum Jun 23, 2004 FDA has no questions
  141
Polyvinyl alcohol Apr 28, 2004 FDA has no questions
  140
Crystalline lutein Jun 14, 2004 FDA has no questions; some uses may require a color additive listing Jul 29, 2016
  139
Cassia gum
   (Resubmission of GRN 51)
May 3, 2004 At the notifier's request, FDA ceased to evaluate this notice
  138
Fish oil Apr 20, 2004 FDA has no questions
  137
Algal oil (Schizochytrium sp.) Feb 12, 2004 FDA has no questions
  136
Calcium gluconate Feb 5, 2004 FDA has no questions
  135
ε-Polylysine Jan 16, 2004 FDA has no questions
  134
Soy protein hydrolyzate with enzyme-modified lecithin Jan 8, 2004 FDA has no questions
  133
Volatile oil of mustard Jan 5, 2004 FDA has no questions
  132
Lactase enzyme preparation from Aspergillus niger Dec 12, 2003 FDA has no questions

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GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
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