• Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

GRAS Notices

  • Print
  • Share
  • E-mail
-

The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


Search and display hints:

  • Select the specific GRN number below to view additional details about any GRAS Notice.
  • To sort by a specific field, click on the column header for that field.
  • To browse the records, use the Show All, First/Previous/Next/Last, and Jump To options at the bottom of the data table.
  • To search for a specific substance/term, enter the term in the Search box and select Show Items to display only those records that contain the selected term. (The search results also includes terms not shown on this page, but included in the full record on the detail page.)
  • The search results will return hits of records containing words that include the search term. For example, a search for the color red will return results that include terms such as reduce, ingredient, and cultured. To limit results to only the searched term, place a space before and after the word in the basic search or in the advanced search “this exact phrase” field.
Download GRAS Notices data in Microsoft Excel web format Download data from this searchable database in Excel format. If you need help accessing information in different file formats, see Instructions for Downloading Viewers and Players.
Search within these results
Records Found: 1041 Show All Page 21 of 21
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
41 DHASCO (docosahexaenoic acid-rich single-cell oil) and ARASCO (arachidonic acid-rich single-cell oil) May 17, 2001 FDA has no questions
40 Mineral oil Dec 11, 2000 Notice does not provide a basis for a GRAS determination
39 Tall oil phytosterols Apr 24, 2000 FDA has no questions (additional correspondence available)
38 Cetylpyridinium chloride Feb 29, 2000 Notice does not provide a basis for a GRAS determination
37 Whey protein isolate and dairy product solids Apr 21, 2000 FDA has no questions (additional correspondence available)
36 Chromium picolinate; Ginkgo biloba leaf extract; and Ginseng extract Apr 10, 2000 At notifier's request, FDA ceased to evaluate the notice
35 Hempseed oil Aug 24, 2000 Notice does not provide a basis for a GRAS determination
34 Aspartic proteinase derived from Aspergillus oryzae carrying a gene encoding aspartic proteinase from Rhizomucor miehei Apr 19, 2000 FDA has no questions
33 Low erucic acid oil derived from Brassica juncea Jan 27, 2000 FDA has no questions
32 Pectin lyase derived from Trichoderma reesei carrying a gene encoding pectin lyase from Aspergillus niger Apr 20, 2000 FDA has no questions
31 Cetylpyridinium chloride Jan 10, 2000 At notifier's request, FDA ceased to evaluate the notice.
30 Crospovidone-cranberry juice extract Dec 20, 1999 Notice does not provide a basis for a GRAS determination (additional correspondence available)
29 Transglutaminase from Streptoverticillium mobaraense Dec 29, 1999 FDA has no questions
28 Seaweed-derived calcium Apr 21, 2000 FDA has no questions (additional correspondence available)
27 Dextranase from Chaetomium gracile Dec 16, 1999 FDA has no questions
26 Isolated wheat protein Dec 16, 1999 FDA has no questions
25 Extract of Garcinia kola seed ("bitter cola") Oct 12, 1999 Notice does not provide a basis for a GRAS determination
24 alpha-Amylase derived from Bacillus licheniformis carrying a gene encoding alpha-amylase from Bacillus stearothermophilus May 15, 2000 FDA has no questions
23 Protein preparation from animal blood Aug 2, 1999 At notifier's request, FDA ceased to evaluate the notice
22 alpha-Amylase derived from Bacillus licheniformis carrying a gene encoding a modified alpha-amylase derived from Bacillus lichenformis and Bacillus amyloliquefaciens Dec 29, 1999 FDA has no questions
21 Pork collagen Jul 29, 1999 FDA has no questions
20 Pullulanase derived from Bacillus subtilis carrying a gene encoding pullulanase from Bacillus naganoensis Sep 30, 1999 FDA has no questions
19 Ferrous bisglycinate chelate Sep 30, 1999 FDA has no questions
18 Mesquite (Prosopis spp.) wood alcoholic extract May 12, 1999 FDA has no questions
17 Arabinogalactan Apr 11, 2000 At notifier's request, FDA ceased to evaluate the notice.
16 Menhaden oil Jun 8, 1999 At notifier's request, FDA ceased to evaluate the notice
15 Tasteless smoke Mar 10, 2000 FDA has no questions
14 Hydrogen peroxide May 26, 1999 Notice does not provide a basis for a GRAS determination
13 Botanicals: Chrysanthemum; Licorice; Jellywort AND
Honeysuckle; Lophatherum; Mulberry leaf; Frangipani; Selfheal; Sophora flower bud
Jun 2, 1999 Notice does not provide a basis AND
FDA has no questions
12 Mesquite wood alcoholic extract Mar 11, 1999 At notifier's request, FDA ceased to evaluate the notice.
11 Calcium casein peptone-calcium phosphate Jan 29, 1999 FDA has no questions
10 Exopeptidase derived from Aspergillus oryzae carrying a gene encoding a leucine aminopeptidase from Aspergillus sojae Jan 29, 1999 Notice does not provide a basis for a GRAS determination
9 Polyglycerol polyricinoleic acid Mar 2, 1999 FDA has no questions
8 Pectin esterase derived from Aspergillus oryzae carrying a gene encoding pectin esterase from Aspergillus aculeatus Mar 2, 1999 FDA has no questions
7 ARASCO (arachidonic acid-rich single-cell oil) and DHASCO (docosahexaenoic acid-rich single-cell oil) as sources of the fatty acids ARA (arachidonic acid) and DHA (docosahexaenoic acid) Mar 4, 1999 Notice does not provide a basis for a GRAS determination.
6 Dioctyl sodium sulfosuccinate Dec 28, 1998 FDA has no questions
5 Tasteless smoke Nov 9, 1998 At notifier's request, FDA ceased to evaluate the notice.
4 Transglutaminase from Streptoverticillium mobaraense Jun 22, 1998 FDA has no questions
3 Sodium bisulfate Jun 5, 1998 FDA has no questions
2 Solin oil (low linolenic acid flaxseed oil or low linolenic acid linseed oil) May 27, 1998 FDA has no questions
1 Soy isoflavone extract Nov 3, 1998 At notifier's request, FDA ceased to evaluate the notice

Show All 

jump to page of 21 


GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

96  

-
-