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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 1027 Show All Page 3 of 21
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
927 Polyvinyl alcohol Feb 26, 2021 FDA has no questions (in PDF) (206 kB)
926 Soluble rice flour Jan 5, 2021 FDA has no questions (in PDF) (434 kB)
925 3-fucosyllactose Feb 8, 2021 FDA has no questions (in PDF) (190 kB)
924 2'-fucosyllactose Nov 23, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF)
923 Lacto-N-tetraose Feb 2, 2021 FDA has no questions (in PDF) (187 kB)
922 6'-sialyllactose sodium salt Apr 23, 2021 FDA has no questions (in PDF) (224 Kb)
921 3'-sialyllactose sodium salt Oct 30, 2020 FDA has no questions (in PDF) (771 kB)
920 Thaumatin II Nov 24, 2020 FDA has no questions (in PDF) (170 kB)
919 Lacto-N-neotetraose Oct 30, 2020 FDA has no questions (in PDF) (353 kB)
918 Partially defatted almond protein flour Pending
917 Preparation containing three bacterial phages specific to Salmonella Sep 10, 2020 FDA has no questions (in PDF) (540 kB)
916 Dihydroquercetin May 19, 2021 FDA has no questions (in PDF) (245 kB)
915 Calcium L-methylfolate Feb 23, 2021 FDA has no questions (in PDF) (217 kB)
914 Alpha-linolenic acid diacylglycerol Mar 15, 2021 FDA has no questions (in PDF) (175 kB)
913 Algal oil (minimum 35% DHA) Nov 10, 2020 FDA has no questions (in PDF) (906 kB)
912 Trehalose Oct 1, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (141 kB)
911 Rebaudioside I Jun 8, 2021 FDA has no questions (in PDF) (208 kB)
910 Thaumatin II Sep 9, 2020 FDA has no questions (in PDF) (541 kB)
909 Whey protein containing 41% alpha-lactalbumin Sep 8, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (127 kB)
908 Lipase from Penicillium camemberti FDA has no questions (in PDF) (184 kB)
907 Wheat seed oil Aug 21, 2020 FDA has no questions (in PDF) (593 kB)
906 Wheat seed polar lipids Aug 24, 2020 FDA has no questions (in PDF) (573 kB)
905 Bacillus subtilis SG188 Jun 8, 2020 FDA has no questions (in PDF) (659 kB)
904 Fungal protein from fermented Fusarium sp. mycelia Mar 26, 2021 FDA has no questions (in PDF) (956 kB)
903 Quillaia extract type 2 Apr 21, 2021 FDA has no questions (in PDF) (195 kB)
902 Neohesperidin dihydrochalcone Nov 23, 2020 FDA has no questions (in PDF) (409 kB)
901 Glucosyl hesperidin Nov 9, 2020 FDA has no questions (in PDF) (670 kB)
900 Corn oil Oct 30, 2020 FDA has no questions (in PDF) (540 kB)
899 Citric acid esters of mono- and diglycerides Oct 30, 2020 FDA has no questions (in PDF) (624 kB)
898 Anhydrous milk fat Oct 28, 2020 FDA has no questions (in PDF) (650 kB)
897 2-O-fucosyllactose Jun 12, 2020 FDA has no questions (in PDF) (715 kB)
896 Alpha-galacto-oligosaccharides Sep 18, 2020 FDA has no questions (in PDF) (202 kB)
895 Lacto-N-neotetraose Dec 3, 2020 FDA has no questions (in PDF) (858 kB)
894 White mulberry leaf extract Nov 19, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (201 kB)
893 D-psicose Jun 5, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (58 kB)
892 Refined shea butter Jul 7, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (162 kB)
891 Cellulase produced by Trichoderma reesei Oct 20, 2020 FDA has no questions (in PDF)
890 Corn oil derived from distillers grains Dec 23, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (189 kB)
889 Spermidine rich wheat germ extract Mar 20, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (236 kB)
888 Preparation containing three bacterial phages specific to Salmonella Feb 28, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (36 KB)
887 Menaquinone-7 Jun 12, 2020 FDA has no questions (in PDF) (472 kB)
886 Monoacylglycerides from grape seed Jul 13, 2020 FDA has no questions (additional correspondence available) (508 kB)
885 Vinyl acetate-vinyl laurate copolymer Apr 22, 2020 FDA has no questions (in PDF) (451 kB)
884 Rice bran extract Aug 19, 2020 FDA has no questions (in PDF) (518 kB)
883 Ilex guayusa leaf aqueous extract Apr 28, 2020 FDA has no questions (in PDF) (46 KB)
882 Rebaudioside M Feb 2, 2020 FDA has no questions (in PDF) (479 kB)
881 6'-sialyllactose sodium salt Feb 24, 2020 FDA has no questions (in PDF) (562 kB)
880 3'-sialyllactose sodium salt Feb 21, 2020 FDA has no questions (in PDF) (557 kB)
879 Fava bean protein isolate Mar 23, 2020 FDA has no questions (in PDF) (502 KB)
878 Glucosylated steviol glycosides Dec 19, 2019 FDA has no questions (additional correspondence available) (453 kB)

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GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

2362  

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