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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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Records Found: 1041 Show All Page 1 of 21
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
1041 Dry whole milk May 10, 2022 FDA has no questions (in PDF) (2.0 MB)
1040 2'-fucosyllactose Pending
1039 Lactase enzyme preparation produced by Aspergillus oryzae Pending
1038 Preparation containing six bacteriophages (phage) specific to Salmonella enterica spp. serovars Pending
1037 3-fucosyllactose Pending
1036 Complexation products of iron with sodium citrate Pending
1035 Lacto-N-fucopentaose I with 2′-fucosyllactose Pending
1034 2'-fucosyllactose Pending
1033 Hydrolyzed Saccharomyces cerevisiae Pending
1032 D-β-hydroxybutyrate Jun 2, 2022 FDA has no questions (in PDF) (214 kB)
1031 Barley and rice protein hydrolysate Pending
1030 Cellulase enzyme preparation produced by Aspergillus niger genetically engineered to express a cellulase gene from Trichoderma reesei Pending
1029 D-psicose Pending
1028 Metschnikowia pulcherrima DANMET-A and M. fructicola DANMET-B Pending
1027 Miracle fruit (Synsepalum dulcificum) powder Dec 22, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (137 kB)
1026 Silk fibroin derived from Bombyx mori cocoons Pending
1025 Pepsin A enzyme preparation produced by Pichia pastoris to overexpress the gene encoding pepsin A Pending
1024 D-psicose Pending
1023 Monosodium L-5-methyltetrahydrofolate Jan 25, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (85 kB)
1022 Streptococcus salivarius DB-B5 Pending
1021 Transglutaminase enzyme preparation produced by Streptomyces mobaraensis strain M2020197 Pending
1020 Protein from Helianthus annuus (sunflower protein) Jun 14, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (101 kB)
1019 Agave mixed fructans from Agave tequilana Weber var. azul Pending
1018 Carbon monoxide Pending
1017 Lacto-N-tetraose Pending
1016 6’-sialyllactose sodium salt Pending
1015 3’-sialyllactose sodium salt Pending
1014 2’-fucosyllactose Pending
1013 Lactobacillus rhamnosus DSM 33156 Dec 15, 2021 FDA has no questions (in PDF) (310 kB)
1012 Powdered sap from Angelica keiskei (ashitaba) containing 8% chalcones (ashitaba sap) Apr 7, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (108 kB)
1011 Alpha-amylase enzyme preparation produced by Bacillus subtilis strain AR-651 expressing the gene encoding alpha-amylase from Thermoactinomyces vulgaris Pending
1010 Rebaudioside M obtained by enzymatic treatment of steviol glycosides purified from the leaves of Stevia rebaudiana (Bertoni) Jan 26, 2022 FDA has no questions (in PDF) (412 kB)
1009 Water-soluble palm fruit extract Pending
1008 Algal oil (≥45% docosahexaenoic acid) from Aurantiochytrium limacinum TKD-1 Feb 25, 2022 FDA has no questions (in PDF) (166 kB)
1007 Bacillus subtilis strain R0179 Pending
1006 Short-chain fructooligosaccharides Jan 19, 2022 FDA has no questions (in PDF) (177 kB)
1005 β-Lactoglobulin from cow milk Mar 3, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF)
1004 Maltosyltrehalose syrup Jan 20, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (84 kB)
1003 Bifidobacterium longum subsp. infantis M-63 Apr 26, 2022 FDA has no questions (in PDF) (75 kB)
1002 Bifidobacterium breve strain MCC1274 Pending
1001 Myoglobin preparation from a strain of Pichia pastoris expressing the myoglobin gene from Bos taurus Dec 3, 2021 FDA has no questions (in PDF) (375 kB)
1000 Phycocyanin-rich extract of Galdieria sulphuraria (G. sulphuraria strain “FCC3424”) Mar 8, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (160 kB)
999 Enzyme-modified steviol glycosides Dec 3, 2021 FDA has no questions (in PDF) (172 kB)
998 Corn bran arabinoxylan Oct 25, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (101 kB)
997 Chitosan and beta-1,3-glucans from white button mushrooms (Agaricus bisporus) Feb 28, 2022 FDA has no questions (in PDF) (140 kB)
996 Synthetic amorphous silica Feb 4, 2022 FDA has no questions (in PDF) (137 kB)
995 β-glucans from Antrodia cinnamomea strain ATCC 200183 Pending
994 Miracle fruit (Synsepalum dulcificum), in pulp, powder, or protein forms Oct 26, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (140 kB)
993 L-carnitine-L-tartrate Oct 18, 2021 FDA has no questions (in PDF) (149 kB)
992 White mulberry (Morus alba Linn) leaf extract May 6, 2022 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (97 kB)

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GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

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