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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.

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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 1027 Show All Page 1 of 21
(sorted Z-A)
Substance Date of closure FDA's Letter
1027 Miracle fruit (Synsepalum dulcificum) powder Pending
1026 Silk fibroin derived from Bombyx mori cocoons Pending
1025 Pepsin A enzyme preparation produced by Pichia pastoris to overexpress the gene encoding pepsin A Pending
1024 D-psicose Pending
1023 Monosodium L-5-methyltetrahydrofolate Pending
1022 Streptococcus salivarius DB-B5 Pending
1021 Transglutaminase enzyme preparation produced by Streptomyces mobaraensis strain M2020197 Pending
1020 Protein from Helianthus annuus (sunflower protein) Pending
1019 Agave mixed fructans from Agave tequilana Weber var. azul Pending
1018 Carbon monoxide Pending
1017 Lacto-N-tetraose Pending
1016 6’-sialyllactose sodium salt Pending
1015 3’-sialyllactose sodium salt Pending
1014 2’-fucosyllactose Pending
1013 Lactobacillus rhamnosus DSM 33156 Pending
1012 Powdered sap from Angelica keiskei (ashitaba) containing 8% chalcones (ashitaba sap) Pending
1011 Alpha-amylase enzyme preparation produced by Bacillus subtilis strain AR-651 expressing the gene encoding alpha-amylase from Thermoactinomyces vulgaris Pending
1010 Rebaudioside M obtained by enzymatic treatment of steviol glycosides purified from the leaves of Stevia rebaudiana (Bertoni) Pending
1009 Water-soluble palm fruit extract Pending
1008 Algal oil (≥35% docosahexaenoic acid) from Aurantiochytrium limacinum TKD-1 Pending
1007 Bacillus subtilis strain R0179 Pending
1006 Short-chain fructooligosaccharides Pending
1005 β-Lactoglobulin from cow milk Pending
1004 Maltosyltrehalose syrup Pending
1003 Bifidobacterium longum subsp. infantis M-63 Pending
1002 Bifidobacterium breve strain MCC1274 Pending
1001 Myoglobin preparation from a strain of Pichia pastoris expressing the myoglobin gene from Bos taurus Dec 3, 2021 FDA has no questions (in PDF) (375 kB)
1000 Phycocyanin-rich extract of Galdieria sulphuraria (G. sulphuraria strain “FCC3424”) Pending
999 Enzyme-modified steviol glycosides Pending
998 Corn bran arabinoxylan Pending
997 Chitosan and beta-1,3-glucans from white button mushrooms (Agaricus bisporus) Pending
996 Synthetic amorphous silica Pending
995 β-glucans from Antrodia cinnamomea strain ATCC 200183 Pending
994 Miracle fruit (Synsepalum dulcificum), in pulp, powder, or protein forms Oct 26, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (140 kB)
993 L-carnitine-L-tartrate Oct 18, 2021 FDA has no questions (in PDF) (149 kB)
992 White mulberry (Morus alba Linn) leaf extract Pending
991 Chitonase enzyme preparation produced by Bacillus subtilis Pending
990 Short-chain fructooligosaccharides Oct 8, 2021 FDA has no questions (in PDF) (109 kB)
989 Bacillus subtilis expressing a modified gene encoding a variant of the wild-type subtilisin from B. clausii Pending
988 Lactobacillus fermentum LfQi6 Pending
987 2'-fucosyllactose Pending
986 Chlorella sorokiniana powder and C. sorokiniana micro powder Pending
985 Bifidobacterium longum subsp. infantis strain ATCC SD 6720 Pending
984 Wolffia globosa Oct 8, 2021 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (429 kB)
983 Purified steviol glycosides from the leaves of Stevia rebaudiana (Bertoni) Pending
982 Polygalacturonase enzyme preparation produced by Aspergillus oryzae expressing a polygalacturonase gene from A. tubingensis Mosseray Pending
981 Sterol esterase enzyme preparation produced by Trichoderma reesei expressing a gene encoding sterol esterase from Melanocarpus albomyces Pending
980 Dry whole milk Jul 13, 2021 FDA has no questions (in PDF) (124 kB)
979 Pectin esterase enzyme preparation produced by Aspergillus oryzae expressing a pectin esterase gene from A. tubingensis Pending
978 Hydrolyzed aqueous olive pulp extract Dec 10, 2021 FDA has no questions (in PDF) (256 kB)

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(sorted Z-A)
Substance Date of closure FDA's Letter